ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2009, Vol. 1 ›› Issue (5): 448-449.

• 论著 • 上一篇    下一篇

小儿利咽康颗粒剂免疫调节作用的实验观察

  

  1. 110101 沈阳,辽宁中医药大学职业技术学院医学基础部
  • 出版日期:2009-10-25 发布日期:2019-06-14
  • 通讯作者: 宋光熠,110101 沈阳,辽宁中医药大学职业技术学院医学基础部。
  • 作者简介:王实(1966-),男,讲师。研究方向:组织病理学研究。

  • Online:2009-10-25 Published:2019-06-14

摘要: 目的观察小儿利咽康颗粒剂的免疫调节作用。
方法采用大鼠腹腔注射羟甲基纤维素钠致炎诱发白细胞游走,涂抹二硝基氟苯诱导小鼠迟发型超敏反应,小鼠尾静脉注射胶体碳悬液,腹腔注射10%羊红细胞免疫小鼠,观察小儿利咽康颗粒剂对羟甲基纤维素钠致炎诱发白细胞游走的抑制作用,对二硝基氟苯诱导小鼠迟发型超敏反应、对小鼠血中碳粒清除速度、对小鼠血清凝集素的影响。
结果JP2〗小儿利咽康颗粒剂可明显抑制白细胞游走作用,对二硝基氟苯致小鼠迟发型超敏反应有明显的抑制作用,对小鼠血中碳粒清除速度和小鼠血清凝集素的影响不明显。
结论小儿利咽康颗粒剂具有一定的免疫调节作用。

关键词: 炎症;中草药/治疗;大鼠, Wistar;小鼠;动物, 实验

Abstract: ObjectiveWT5”BZ〗To observe immune regulation effect of Liyankang granule on children.
WT5”HZ〗MethodsWT5”BZ〗The present study has been carried out using NaCMC injected into the mice's abdominal cavity to cause inflammation and induce white blood cell migration,varnishing DNFB to induce mice's DTH,injecting colloid activated carbon suspension into mice's tail vein,with 10% of sheep RBC injected into the abdomen to immunize mice.We observed inhibitory function of Liyankang granule on NaCMC to cause inflammation and induce white blood cell migration,the effect of DNFB on inducing mice's DTH and the effect on clearance speed of carbon particle in mice's blood and serum agglution of mice.
WT5”HZ〗ResultsWT5”BZ〗Liyankang granule for children could obviouly inhibit migration of white blood cells,having obvious effect on inhibiting DNFB to mice's DTH,but the effect on clearance speed of carbon particle in mice's blood and serum agglutinin of mice was not obvious.
WT5”HZ〗ConclusionWT5”BZ〗Liyankang granule for children has certain immune regulation effect.

Key words: Inflammation;Traditional Chinese drug/Therapy;Animals, laboratory;Rats, Wistar;Mice