ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2009, Vol. 1 ›› Issue (1): 33-36.doi: 10.3969/j.issn.1674-3865.2009.01.012

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以宿痰伏肺立论治疗支气管哮喘缓解期临床探讨

郭振武，张雅凤，林忠嗣，乔世举，于雪峰，张楚石   

  1. 110034 沈阳，辽宁中医药大学附属第二医院儿科
  • 收稿日期:2008-07-21 出版日期:2009-02-25 上线日期:2009-02-25
  • 通讯作者: 张雅凤，E-mail：linzhs@sohu.com
  • 作者简介:郭振武（1951-），男，教授、主任医师，博士研究生导师。研究方向：中医药治疗小儿呼吸系统疾病。
  • 基金资助:
    国家中医药管理局中医药行业科研专项项目实施方案“金龙定喘治疗哮喘方、证、效评价方案研究”（200807034）

Clinical study on the treatment for bronchial asthma in remission stage based on the theory of old phlegm in lung

GUO Zhen wu，ZHANG Ya feng，LIN Zhong si   

  1. Department of Pediatrics,The Second  Affiliated Hospital to Liaoning University of TCM，Shenyang 110034，China
  • Received:2008-07-21 Published:2009-02-25 Online:2009-02-25

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摘要： 目的：以宿痰伏肺理论为依据探讨缓解期支气管哮喘患儿临床疗效的可行性。方法：将200例支气管哮喘缓解期患儿分为两组，金龙固本合剂口服观察组和辅舒酮吸入对照组各100例。临床治疗2个月后随访2年，观察患儿疗效和外周血嗜酸性粒细胞计数（EOS），IgG，IgE，T细胞亚群及肺功能的变化。结果：治疗前后的自身对照，观察组每年的哮喘复发次数较治疗前明显减少，患儿EOS明显降低，T淋巴细胞亚群CD8明显增加，CD4/CD8细胞比值降低，肺功能明显改善（P＜005）。结论：采用以宿痰伏肺为理论依据研制的金龙固本合剂治疗缓解期支气管哮喘患者临床疗效明显。免疫功能紊乱是引起支气管哮喘反复发作的重要因素，采用固本化痰法运用中医药调节免疫功能，为哮喘缓解期的中医药治疗提供理论依据。

关键词: 哮喘/中医药疗法, T淋巴细胞, 金龙固本合剂, 病机

Abstract: Objective：To probe into the feasibility of clinical treatment for bronchial asthma in remission stage based on the theory of old phlegm in lung.Methods：Totally 200 cases of bronchial asthma in remission stage were divided into two groups，Jinlong Guben mixture of oral treatment and control groups of with 100 cases in each.Clinical treatment lasting two months there was a 2-year follow-up，and observe the effects in patients，and peripheral eosinophil counts，serum immunoglobulin IgG，IgE，T cell subsets and changes in lung function.Results：The frequency of recurrence in the treatment group significantly reduced after treatment；eosinophil count decreased significantly；T-lymphocyte subsets of CD8 increased significantly；CD4/CD8 ratio reduced and lung function improved significantly(P<0.05).Conclusion：Jinlong Guben mixture，which is made based on the theory of old phlegn in lung，has significant clinical effect in treating patients with bronchial asthma in remission stage.Immunologic dysfunction is the cause of recurrent attack of bronchial asthma.The dysfunction can be improved by TCM in the way of consolidating foundation and clearing sputum，which provides throretical basis for the TCM treatment for asthma in remission stage.

Key words: Asthma/TCM treatment；T lymphocyte subsets；Jinlong Guben mixture, Pathogenesis