ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2025, Vol. 17 ›› Issue (6): 527-531.doi: 10.20274/j.cnki.issn.1674-3865.2025.06.012

• 中医应用研究 • 上一篇    下一篇

基于“阳化气,阴成形”理论探析性早熟合并肥胖的机制及治疗

邓孟迪1, 张桂菊2()   

  1. 250355 济南,山东中医药大学第一临床医学院2023级中医儿科学专业研究生(邓孟迪)
    250011 济南,山东中医药大学附属医院儿科(张桂菊)
  • 收稿日期:2025-05-29 修回日期:2025-08-06 出版日期:2025-12-25 上线日期:2025-12-31
  • 通讯作者: 张桂菊 E-mail:13685316296@163.com
  • 作者简介:邓孟迪(2000-),女,山东中医药大学第一临床医学院2023级硕士研究生在读。研究方向:小儿呼吸、内分泌系统疾病的诊治
  • 基金资助:
    山东省自然科学基金项目(ZR2023QH158)

Exploring the mechanism and treatment of precocious puberty combined with obesity based on the theory of "Yang transforms qi and yin takes shape"

Mengdi DENG1, Guiju ZHANG2()   

  1. 1.Shandong University of Traditional Chinese Medicine,Jinan 250355,China
    2.Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China
  • Received:2025-05-29 Revised:2025-08-06 Published:2025-12-25 Online:2025-12-31
  • Contact: Guiju ZHANG E-mail:13685316296@163.com
  • Supported by:
    Shandong Provincial Natural Science Foundation(ZR2023QH158)

摘要:

儿童性早熟缩短儿童生长发育时期,并与远期不良健康后果存在相关性。肥胖是性早熟的重要危险因素,二者常并存且机制互涉。张桂菊教授根据《黄帝内经》“阳化气,阴成形”理论,提出肥胖合并性早熟的发病机制具有前期阳化气不足,阴成形过度;中期阳用过度,阴精损耗;后期阴损及阳,阳用不足的特点。治疗强调分期论治:初期温补脾肾阳气、化痰湿消脂浊;中期滋养肾阴、清降相火、疏调气机;后期益肾填精、平衡阴阳、调摄命门。全程贯穿消解痰湿膏脂、调理气机命门之法,旨在温阳化气促代谢、滋阴降火制亢阳、益脾肾助生长,最终恢复阴平阳秘,保障儿童正常发育节律。

关键词: 性早熟, 肥胖, 阳化气,阴成形, 发病机制, 治则治法, 中药, 儿童

Abstract:

Precocious puberty in children shortens the period of growth and development and is associated with adverse long-term health outcomes. Obesity is an important risk factor for precocious puberty, and the two often coexist and their mechanisms are involved in each other. Based on the theory of "Yang transforms qi and yin takes shape" in Huangdi Neijing, Prof. Zhang Guiju proposes that the pathogenesis of obesity combined with precocious puberty is characterized by insufficient yang transforming qi and excessive yin taking shape in the early stage, excessive use of yang and loss of yin essence in the middle stage, and loss of yin involving yang and insufficient use of yang in the late stage. The treatment emphasizes the staged approach: at the early stage, warm and recuperate the spleen and kidney yang qi, transform phlegm dampness, and eliminate fat and turbidity; at the middle stage, nourish the kidney yin, clear and reduce the phlegm-fire, and dredge and regulate qi; at the late stage, tonify the kidney and fill up the essence, balance yin and yang, and regulate the vital organs. The whole process of eliminating phlegm dampness and fat and regulating qi and vital organs is aimed at warming yang and transforming qi to promote metabolism, nourishing yin and reducing fire to control hyperactivity of yang, tonifying the spleen and kidney to assist growth, and ultimately restoring the balance of yin and yang to ensure the normal developmental rhythms in children.

Key words: Precocious puberty, Obesity, Yang transforms qi and yin takes shape, Pathogenesis, Treatment principles and approaches, Medicinal herb, Child

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