健脾益气膏治疗小儿厌食(脾胃气虚证)的疗效观察

doi:10.20274/j.cnki.issn.1674-3865.2025.06.003

摘要/Abstract

摘要：

目的探讨临床对小儿厌食(脾胃气虚证)患者选择健脾益气膏治疗后获得的应用效果。方法选择2023年1月至2024年2月荆州市中医医院儿科收治的小儿厌食(脾胃气虚证)患者100例为研究对象，随机分为对照组和观察组各50例。对照组采用醒脾养儿颗粒口服治疗；观察组采用健脾益气膏口服治疗。观察对比两组小儿厌食(脾胃气虚证)患者的治疗总有效率、治疗前后尿D-木糖排泄率、唾液淀粉酶活性比值、胃泌素水平、胃动素水平、神经肽Y水平、症状积分改善情况、体质量以及身高水平。结果观察组小儿厌食(脾胃气虚证)患者治疗总有效率为98.0%（49/50），显著高于对照组84.0%（42/50），差异有统计学意义（P<0.05）。治疗后观察组尿D-木糖排泄率、唾液淀粉酶活性比值、胃泌素水平、胃动素水平、神经肽Y水平高于对照组，差异有统计学意义（P<0.05）；治疗后观察组各项症状积分（进食量、食欲、进食时间）低于对照组，差异有统计学意义（P<0.05）。治疗前后两组体质量及身高比较差异无统计学意义（P>0.05）。结论健脾益气膏治疗小儿厌食(脾胃气虚证)患者，可明显提升患儿的治疗效果，显著改善其系列临床指标，促进其临床症状的缓解。

关键词: 厌食, 脾胃气虚证, 健脾益气膏, 儿童

Abstract:

Objective To explore the clinical effects of Jianpi Yiqi (tonifying spleen and benefiting qi) ointment in the treatment of pediatric anorexia (spleen stomach qi-deficiency syndrome). Method One hundred children with anorexia(spleen and stomach qi-deficiency syndrome) admitted to the Pediatric Department of Jingzhou Hospital of Traditional Chinese Medicine from January 2023 to February 2024 were selected as the research subjects, and they were randomly divided into a control group and an observation group, each consisting of 50 cases. The control group was treated with oral administration of Xingpi Yanger granules, while the observation group was treated with oral administration of Jianpi Yiqi ointment. The total effective rate of treatment, the excretion rate of urinary D-xylose, the ratio of salivary amylase activity, the levels of gastrin, motilin and neuropeptide Y, the improvement in symptom scores, and the body weight and height before and after treatment were observed and compared between the two groups. Results The total effective rate of treatment for children with anorexia(spleen and stomach qi-deficiency syndrome) in the observation group was 98.0%(49/50), significantly higher than that in the control group (84.0%, 42/50), with a statistically significant difference(P<0.05). After treatment, the urine D-xylose excretion rate, salivary amylase activity ratio, gastrin level, motilin level, and neuropeptide Y level in the observation group were higher than those in the control group, with statistically significant differences(P<0.05). After treatment, the symptom scores(food intake, appetite, and eating time) in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). There was no statistically significant difference in body weight or height between the two groups before and after treatment(P>0.05). Conclusion Jianpi Yiqi ointment in the treatment of children with anorexia(spleen and stomach qi-deficiency syndrome) can significantly improve the therapeutic effect on the children, significantly improve a series of clinical indicators in them, and promote the relief of the clinical symptoms.

Key words: Anorexia, Spleen and stomach qi-deficiency syndrome, Jianpi Yiqi ointment, Child

中图分类号:

R442.1

唐其民, 涂一世. 健脾益气膏治疗小儿厌食(脾胃气虚证)的疗效观察[J]. 中国中西医结合儿科学, 2025, 17(6): 472-476.

Qimin TANG, Yishi TU. Observation on the curative effect of Jianpi Yiqi ointment in treating anorexia(spleen and stomach qi-deficiency syndrome) in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(6): 472-476.

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组别	n	显效	有效	无效	总有效
对照组	50	22（44.0）	20（40.0）	8（16.0）	42（84.0）
观察组	50	40（80.0）	9（18.0）	1（2.0）	49（98.0）^a

组别	n	尿D-木糖排泄率(%)		唾液淀粉酶活性比值
组别	n	治疗前	治疗后	治疗前		治疗后
对照组	50	15.88±2.98	22.45±3.73^a	0.93±0.04		1.02±0.13^a
观察组	50	15.83±2.99	28.72±5.15^a	0.92±0.03		1.29±0.22^a
t值		0.084	6.972	1.414		7.471
P值		0.933	0.000	0.161		0.000
组别	n	胃泌素（ng/L）		胃动素（ng/L）		神经肽Y（ng/L）
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	50	128.19±17.62	159.72±20.43^a	175.51±19.61	237.33±23.19^a	25.59±5.39	36.83±6.75^a
观察组	50	128.15±17.59	181.59±16.22^a	175.49±19.49	280.19±22.69^a	26.39±5.89	46.55±8.19^a
t值		0.011	5.928	0.005	9.341	0.709	6.476
P值		0.991	0.000	0.996	0.000	0.480	0.000

组别	n	进食量		食欲		进食时间
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	50	5.11±0.29	1.82±0.25^a	5.15±0.23	1.62±0.42^a	5.08±0.23	1.42±0.14^a
观察组	50	5.09±0.25	0.49±0.13^a	5.13±0.22	0.53±0.15^a	5.07±0.22	0.62±0.13^a
t值		0.369	33.375	0.444	17.282	0.222	29.609
P值		0.713	0.000	0.658	0.000	0.825	0.000

组别	n	体质量（kg）		身高（m）
组别	n	治疗前	治疗后	治疗前	治疗后
对照组	50	19.54±5.13	19.69±5.22	1.09±0.15	1.12±0.19
观察组	50	19.53±5.15	19.76±5.42	1.09±0.11	1.13±0.15
t值		0.010	0.066	0.000	0.292
P值		0.992	0.948	1.000	0.771