消积理脾散与厌食贴联合常规治疗儿童厌食症（脾失健运证）的临床观察

doi:10.20274/j.cnki.issn.1674-3865.2025.06.001

中国中西医结合儿科学 ›› 2025, Vol. 17 ›› Issue (6): 461-465.doi: 10.20274/j.cnki.issn.1674-3865.2025.06.001

• 儿童脾胃病中医治疗专栏 • 下一篇

消积理脾散与厌食贴联合常规治疗儿童厌食症（脾失健运证）的临床观察

蔡瑞琪¹, 郝欧美²(), 王雪峰², 张柯欣¹

110847 沈阳，辽宁中医药大学2023级中医儿科学专业研究生（蔡瑞琪，张柯欣）
110032 沈阳，辽宁中医药大学附属医院儿科（郝欧美，王雪峰）

收稿日期:2025-05-29 修回日期:2025-08-15 出版日期:2025-12-25 上线日期:2025-12-31
通讯作者: 郝欧美 E-mail:24569573@qq.com
作者简介:蔡瑞琪（2000-），女，辽宁中医药大学2023级硕士研究生在读。研究方向：中医药防治小儿肺脾系疾病
基金资助:
国家自然科学基金面上项目(82274580)

Clinical observation of Xiaoji Lipi powder and anorexia plaster combined with conventional treatment for children with anorexia(spleen dysfunction syndrome)

Ruiqi CAI¹, Oumei HAO²(), Xuefeng WANG², Kexin ZHANG¹

^1.Liaoning University of Traditional Chinese Medicine，Shenyang 110847, China
^2.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110032, China

Received:2025-05-29 Revised:2025-08-15 Published:2025-12-25 Online:2025-12-31
Contact: Oumei HAO E-mail:24569573@qq.com
Supported by:
National Natural Science Foundation of China(82274580)

摘要/Abstract

摘要：

目的观察消积理脾散与厌食贴联合常规治疗儿童厌食症脾失健运证的疗效及对患儿中医证候积分、微量元素以及血红蛋白的影响。方法选择2023年10月至2024年12月于辽宁中医药大学附属医院儿科门诊就诊的厌食症患儿86例为研究对象，随机分为对照组与观察组各43例。对照组予口服赖氨酸肌醇维生素B₁₂口服液治疗，观察组在对照组治疗基础上增加消积理脾散与厌食贴。两组疗程均为4周。比较两组患儿的中医证候积分、疗效、微量元素（Zn、Fe、Ca）、血红蛋白以及不良反应。结果观察组患儿治疗有效率为95.35%（41/43），高于对照组81.40%（35/43），差异有统计学意义（P<0.05）。治疗后两组患儿在食欲不振、食量减少、呃逆嗳气、腹胀、面色少华、大便失调等症状评分及总积分均较治疗前显著下降，且观察组在各项症状评分及总积分的改善幅度均显著优于对照组，差异有统计学意义（P<0.05）。治疗后两组微量元素（Zn、Fe、Ca）以及血红蛋白水平均较治疗前明显提高，且观察组各项指标水平的提升程度显著优于对照组，差异有统计学意义（P<0.05）。两组不良反应情况比较差异无统计学意义（P>0.05）。结论应用消积理脾散与厌食贴联合常规治疗儿童厌食症脾失健运证，可以显著改善食欲，增加食量，促进营养状态恢复以及微量元素吸收，疗效显著并且安全可靠，值得推广。

关键词: 厌食症, 脾失健运证, 消积理脾散, 厌食贴, 赖氨酸肌醇维生素B₁₂, 儿童

Abstract:

Objective To observe the efficacy of Xiaoji Lipi powder and anorexia plaster combined with conventional treatment for children with anorexia of spleen dysfunction syndrome, as well as its effects on TCM syndrome scores, trace elements and hemoglobin in children. Methods A total of 86 children with anorexia who visited the Pediatric Outpatient Department of Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from October 2023 to December 2024 were selected as research subjects. They were randomly divided into a control group and an observation group, with 43 cases in each group. Both groups were treated with oral lysine inositol vitamin B₁₂ oral liquid, while the observation group was additionally given Xiaoji Lipi powder and anorexia plaster. Both groups received a 4-week course of treatment. TCM syndrome scores, efficacy, trace elements(Zn, Fe, Ca), hemoglobin and adverse reactions were compared between the two groups. Results The effective rate of the observation group was 95.35%(41/43), which was higher than 81.40%(35/43) of the control group, and there was a statistically significant difference(P<0.05). After treatment, the scores of symptoms, such as poor appetite, reduced food intake, hiccups and belching, abdominal distension, sallow complexion and irregular defecation, as well as the total scores in both groups were significantly lower than those before treatment；moreover, the improvement of each symptom score and total score in the observation group was significantly better than that in the control group, there were statistically significant differences(P<0.05). After treatment, the levels of trace elements(Zn, Fe, Ca) and hemoglobin in both groups were significantly higher than those before treatment, and the improvement of each index in the observation group was significantly superior to that in the control group， there were statistically significant differences(P<0.05). There was no statistically significant difference in adverse reactions between the two groups(P>0.05). Conclusion The application of Xiaoji Lipi powder and anorexia plaster combined with conventional treatment for children with anorexia of spleen dysfunction syndrome can significantly improve appetite, increase food intake, and promote the recovery of nutritional status and the absorption of trace elements. It is significantly effective, safe and reliable, and is worthy of promotion.

Key words: Anorexia, Spleen dysfunction syndrome, Xiaoji Lipi powder, Anorexia plaster, Lysine inositol vitamin B₁₂, Child

中图分类号:

R442.1

蔡瑞琪, 郝欧美, 王雪峰, 张柯欣. 消积理脾散与厌食贴联合常规治疗儿童厌食症（脾失健运证）的临床观察[J]. 中国中西医结合儿科学, 2025, 17(6): 461-465.

Ruiqi CAI, Oumei HAO, Xuefeng WANG, Kexin ZHANG. Clinical observation of Xiaoji Lipi powder and anorexia plaster combined with conventional treatment for children with anorexia(spleen dysfunction syndrome)[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(6): 461-465.

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参考文献 30

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组别	n	食欲不振		食量减少		呃逆嗳气		腹胀
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	43	3.67±1.44	1.40±1.48^a	3.86±1.41	1.16±1.25^a	1.47±0.86	0.65±0.81^a	1.60±0.82	0.63±0.73^a
观察组	43	3.86±1.41	0.70±1.15^a	3.81±1.44	0.42±0.82^a	1.37±0.85	0.30±0.56^a	1.56±0.83	0.33±0.52^a
t值		-0.61	2.44	0.15	3.26	0.51	2.32	0.26	2.22
P值		0.550	0.017	0.880	0.002	0.613	0.023	0.794	0.029
组别	n	面色少华		大便失调		形体消瘦		总积分
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	43	1.44±0.91	0.67±0.84^a	1.86±0.89	0.98±0.94^a	2.05±0.82	1.79±0.71^a	14.09±3.87	5.23±4.50^a
观察组	43	1.47±0.88	0.33±0.57^a	1.81±0.98	0.47±0.67^a	2.00±0.82	1.44±0.67^a	13.88±3.81	2.53±2.99^a
t值		-0.12	2.26	0.23	2.91	0.25	2.35	0.25	3.28
P值		0.904	0.027	0.820	0.005	0.800	0.021	0.801	0.002

组别	n	痊愈	显效	有效	无效	总有效
对照组	43	11(25.58)	11(25.58)	13(30.23)	8(18.60)	35（81.40）
观察组	43	19(44.19)	16(37.21)	6(13.95)	2(4.65)	41（95.35）^a

组别	n	血清Zn（μmol/L）		血清Ca（mmol/L）		血清Fe（μmol/L）		血红蛋白（g/L）
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	43	10.60±1.35	15.89±1.93^a	1.55±0.13	1.81±0.14^a	7.38±0.49	8.88±0.36^a	110.25±8.24	120.15±8.21^a
观察组	43	10.25±1.06	17.42±2.11^a	1.50±0.14	1.90±0.12^a	7.49±0.47	9.14±0.50^a	110.64±8.19	124.84±7.84^a
t值		1.32	-3.52	1.56	-3.05	-1.06	-2.78	-0.22	-2.71
P值		0.189	0.001	0.123	0.003	0.292	0.007	0.827	0.008

消积理脾散与厌食贴联合常规治疗儿童厌食症（脾失健运证）的临床观察

Clinical observation of Xiaoji Lipi powder and anorexia plaster combined with conventional treatment for children with anorexia(spleen dysfunction syndrome)

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