肠道菌群参与新生儿黄疸的机制及研究进展

doi:10.20274/j.cnki.issn.1674-3865.2025.05.004

中国中西医结合儿科学 ›› 2025, Vol. 17 ›› Issue (5): 382-386.doi: 10.20274/j.cnki.issn.1674-3865.2025.05.004

肠道菌群参与新生儿黄疸的机制及研究进展

彭鑫, 王雨倩, 杨柳()

116021 大连，大连医科大学附属第二医院2023级儿科学专业研究生（彭鑫）
大连医科大学附属第二医院新生儿科（王雨倩，杨柳）

收稿日期:2025-05-13 修回日期:2025-06-11 出版日期:2025-10-25 上线日期:2025-10-25
通讯作者: 杨柳 E-mail:439140628@qq.com
作者简介:彭鑫（1999-），女，大连医科大学2023级硕士研究生在读。研究方向：新生儿围产期感染及脑损伤研究
基金资助:
国家自然科学基金项目(82201896)

Mechanism and research progress of gut microbiota involved in neonatal jaundice

Xin PENG, Yuqian WANG, Liu YANG()

The Second Hospital of Dalian Medical University, Dalian 116021, China

Received:2025-05-13 Revised:2025-06-11 Published:2025-10-25 Online:2025-10-25
Contact: Liu YANG E-mail:439140628@qq.com
Supported by:
National Natural Science Foundation of China Project(82201896)

摘要/Abstract

摘要：

新生儿期是肠道菌群定植与免疫系统发育的关键时期，会对个体健康产生深远影响。新生儿黄疸作为新生儿期最常见的临床症状，其病理过程与胆红素代谢失衡密切相关，而肠道菌群通过调控肠肝循环在胆红素代谢中发挥重要作用。本综述系统梳理了新生儿肠道菌群的构成、发育过程，深入剖析其在胆红素代谢中的作用及对胆红素水平的影响，详细阐述了酶促反应、免疫调节、肠道屏障功能等影响胆红素代谢的可能机制，旨在为临床防治新生儿黄疸提供理论依据，助力新生儿健康发展。

关键词: 新生儿黄疸, 肠道菌群, 肠肝循环, 双歧杆菌

Abstract:

The neonatal period represents a critical period for gut microbiota colonization and immune system development, exerting profound impacts on individual health. Neonatal jaundice is the most common clinical manifestation during this period, and its pathological process is closely associated with the imbalance of bilirubin metabolism. Gut microbiota plays a pivotal role in bilirubin metabolism through regulating the enterohepatic circulation. This review systematically reviews the composition and development of neonatal gut microbiota, provides an in-depth analysis of its role in bilirubin metabolism and its effects on serum bilirubin levels, and elaborates in detail on the potential mechanisms of enzymatic reactions, immune regulation and intestinal barrier function that affect bilirubin metabolism. The aim is to provide theoretical basis for clinical prevention and treatment of neonatal jaundice, thereby promoting the healthy development of neonates.

Key words: Neonatal jaundice, Gut microbiota, Enterohepatic circulation, Bifidobacterium

中图分类号:

R722.17

彭鑫, 王雨倩, 杨柳. 肠道菌群参与新生儿黄疸的机制及研究进展[J]. 中国中西医结合儿科学, 2025, 17(5): 382-386.

Xin PENG, Yuqian WANG, Liu YANG. Mechanism and research progress of gut microbiota involved in neonatal jaundice[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(5): 382-386.

参考文献 40

[1]	Cuna A, Morowitz MJ, Ahmed I, et al. Dynamics of the preterm gut microbiome in health and disease[J]. Am J Physiol Gastrointest Liver Physiol, 2021, 320(4): G411-419.
[2]	Ardissone AN, de la Cruz DM, Davis-Richardson AG, et al. Meconium microbiome analysis identifies bacteria correlated with premature birth[J]. PLoS One, 2014, 9(3): e90784.
[3]	Ma G, Shi Y, Meng L, et al. Factors affecting the early establishment of neonatal intestinal flora and its intervention measures[J]. Front Cell Infect Microbiol, 2023, 13: 1295111.
[4]	Selma-Royo M, Dubois L, Manara S, et al. Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year[J]. Cell Host Microbe, 2024, 32(6): 996-1010.
[5]	Bittinger K, Zhao C, Li Y, et al. Bacterial colonization reprograms the neonatal gut metabolome[J]. Nat Microbiol, 2020, 5(6): 838-847.
[6]	Orrhage K, Nord CE. Factors controlling the bacterial colonization of the intestine in breastfed infants[J]. Acta Paediatr Suppl, 1999, 88(430): 47-57.
[7]	Ding J, Ma X, Han L, et al. Gut microbial alterations in neonatal jaundice pre- and post-treatment[J]. Biosci Rep, 2021, 41(4): BSR20210362.
[8]	Collado MC, Cernada M, Baüerl C, et al. Microbial ecology and host-microbiota interactions during early life stages[J]. Gut Microbes, 2012, 3(4): 352-365.
[9]	Pantazi AC, Balasa AL, Mihai CM, et al. Development of gut microbiota in the first 1000 days after birth and potential interventions[J]. Nutrients, 2023, 15(16): 3647.
[10]	Grech A, Collins CE, Holmes A, et al. Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis[J]. Gut Microbes, 2021, 13(1): 1-30.
[11]	张坤, 樊赛男, 吕安平, 等. 生命早期肠道菌群建立的影响因素[J]. 临床与病理杂志, 2020, 40(4): 1028-1032.
[12]	Pabst O, Hornef MW, Schaap FG, et al. Gut–liver axis: barriers and functional circuits[J]. Nat Rev Gastroenterol Hepatol, 2023, 20(7): 447-461.
[13]	Chen MJ, Liu C, Wan Y, et al. Enterohepatic circulation of bile acids and their emerging roles on glucolipid metabolism[J]. Steroids, 2021, 165: 108757.
[14]	Su H, Yang S, Chen S, et al. What happens in the gut during the formation of neonatal jaundice-underhand manipulation of gut microbiota[J]? Int J Mol Sci, 2024, 25(16): 8582.
[15]	Gao S, Sun R, Singh R, et al. The role of gut microbial β⁃glucuronidase in drug disposition and development[J]. Drug Discov Today, 2022, 27(10): 103316.
[16]	Pham PL, Dupont I, Roy D, et al. Production of exopolysaccharide by Lactobacillus rhamnosus R and analysis of its enzymatic degradation during prolonged fermentation[J]. Appl Environ Microbiol, 2000, 66(6): 2302-2310.
[17]	Hoyles L, Inganäs E, Falsen E, et al. Bifidobacterium scardovii sp. nov., from human sources[J]. Int J Syst Evol Microbiol, 2002, 52(3): 995-999.
[18]	Beaud D, Tailliez P, Anba-Mondoloni J. Genetic characterization of the beta-glucuronidase enzyme from a human intestinal bacterium, Ruminococcus gnavus [J]. Microbiology (Reading), 2005, 151(Pt 7): 2323-2330.
[19]	Salleh HM, Müllegger J, Reid SP, et al. Cloning and characterization of Thermotoga maritima beta-glucuronidase[J]. Carbohydr Res, 2006, 341(1): 49-59.
[20]	Midtvedt T, Gustafsson BE. Microbial conversion of bilirubin to urobilins in vitro and in vivo [J]. Acta Pathol Microbiol Scand B, 1981, 89(2): 57-60.
[21]	Zhou S, Wang Z, He F, et al. Association of serum bilirubin in newborns affected by jaundice with gut microbiota dysbiosis[J]. J Nutr Biochem, 2019, 63: 54-61.
[22]	Rocha Martin VN, Lacroix C, Killer J, et al. Cutibacterium avidum is phylogenetically diverse with a subpopulation being adapted to the infant gut[J]. Syst Appl Microbiol, 2019, 42(4): 506-516.
[23]	Thongaram T, Hoeflinger JL, Chow J, et al. Prebiotic galactooligosaccharide metabolism by probiotic lactobacilli and bifidobacteria[J]. J Agric Food Chem, 2017, 65(20): 4184-4192.
[24]	Hall B, Levy S, Dufault-Thompson K, et al. BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen[J]. Nat Microbiol, 2024, 9(1): 173-184.
[25]	Mei J, Wu X, Zheng S, et al. Production of bilirubin by biotransformation of biliverdin using recombinant Escherichia coli cells[J]. Bioprocess Biosyst Eng, 2022, 45(3): 563-571.
[26]	Koníčková R, Jirásková A, Zelenka J, et al. Reduction of bilirubin ditaurate by the intestinal bacterium Clostridium perfringens [J]. Acta Biochim Pol, 2012, 59(2): 289-292.
[27]	Eghbalian F, Sabzehei MK, Talesh ST, et al. The effect of probiotics on phototherapy for bilirubin reduction in term neonates: a randomized controlled trial[J]. Curr Pediatr Rev, 2024, 21(1): 85-90.
[28]	Nasief H, Alaifan MA, Tamur S, et al. Effectiveness of phototherapy with and without probiotics for the treatment of indirect hyperbilirubinaemia in preterm neonates: a randomised controlled trial[J]. Paediatr Int Child Health, 2024, 44(1): 24-29.
[29]	Deshmukh J, Deshmukh M, Patole S. Probiotics for the management of neonatal hyperbilirubinemia: a systematic review of randomized controlled trials[J]. J Matern Fetal Neonatal Med, 2019, 32(1): 154-163.
[30]	Mutlu M, Aslan Y, Kader Ş, et al. Preventive effects of probiotic supplementation on neonatal hyperbilirubinemia caused by isoimmunization[J]. Am J Perinatol, 2020, 37(11): 1173-1176.
[31]	Zhang X, Zeng S, Cheng G, et al. Clinical manifestations of neonatal hyperbilirubinemia are related to alterations in the gut microbiota[J]. Children (Basel), 2022, 9(5): 764.
[32]	Tuzun F, Kumral A, Duman N, et al. Breast milk jaundice: effect of bacteria present in breast milk and infant feces[J]. J Pediatr Gastroenterol Nutr, 2013, 56(3): 328-332.
[33]	Bortolussi G, Codarin E, Antoniali G, et al. Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice[J]. Cell Death Dis, 2015, 6(5): e1739.
[34]	唐炜, 卢红艳, 孙勤, 等. 高胆红素血症新生儿肠道菌群特点及与β-葡萄糖醛酸苷酶活性的相关性[J]. 中国当代儿科杂志, 2021, 23(7): 677-683.
[35]	Pollet RM, D’Agostino EH, Walton WG, et al. An atlas of β⁃glucuronidases in the human intestinal microbiome[J]. Structure, 2017, 25(7): 967-977.
[36]	Amenyogbe N, Dimitriu P, Smolen KK, et al. Biogeography of the relationship between the child gut microbiome and innate immune system[J]. mBio, 2021, 12(1): e03079-20.
[37]	Henrick BM, Rodriguez L, Lakshmikanth T, et al. Bifidobacteria-mediated immune system imprinting early in life[J]. Cell, 2021, 184(15): 3884-3898.
[38]	Zhou Y, Qin H, Zhang M, et al. Lactobacillus plantarum inhibits intestinal epithelial barrier dysfunction induced by unconjugated bilirubin[J]. Br J Nutr, 2010, 104(3): 390-401.
[39]	Zhou YK, Qin HL, Zhang M, et al. Effects of Lactobacillus plantarum on gut barrier function in experimental obstructive jaundice[J]. World J Gastroenterol, 2012, 18(30): 3977-3991.
[40]	Navarro-Tapia E, Sebastiani G, Sailer S, et al. Probiotic supplementation during the perinatal and infant period: effects on gut dysbiosis and disease[J]. Nutrients, 2020, 12(8): 2243.

肠道菌群参与新生儿黄疸的机制及研究进展

Mechanism and research progress of gut microbiota involved in neonatal jaundice

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 40

相关文章 15

编辑推荐

Metrics

本文评价

[1]	易惺钱, 黄敬滢, 熊智燚, 陈晓凡, 刘英, 李小艳, 王立. 基于文献研究的中国孤独症儿童肠道菌群特征分析[J]. 中国中西医结合儿科学, 2025, 17(4): 302-312.
[2]	薛玲艳, 李建英, 贺春兰, 赵玲莉. 粪便中短链脂肪酸及菌群结构对婴幼儿的影响[J]. 中国中西医结合儿科学, 2025, 17(3): 226-230.
[3]	李建英, 薛玲艳, 贺春兰, 赵玲莉. 母乳中母乳低聚糖对婴儿肠道菌群的影响及研究进展[J]. 中国中西医结合儿科学, 2025, 17(2): 121-125.
[4]	华智超, 陈玉燕, 杨育访, 陈晓玲. 粪菌移植治疗儿童神经发育障碍性疾病的研究进展[J]. 中国中西医结合儿科学, 2025, 17(1): 22-26.
[5]	王格, 张雪荣, 刘雁云, 段云雁, 沈鹤霄. 中枢性性早熟女童肠道菌群分析[J]. 中国中西医结合儿科学, 2024, 16(5): 419-424.
[6]	朱彤彤, 叶进. 肠道菌群与儿童肥胖发病机制的研究进展[J]. 中国中西医结合儿科学, 2023, 15(5): 420-425.
[7]	吴建业, 徐磊, 康贝贝, 姜志梅, 徐瑞阳, 陈宁. 肠道菌群产生的短链脂肪酸影响孤独症谱系障碍核心症状的相关机制研究[J]. 中国中西医结合儿科学, 2022, 14(6): 481-485.
[8]	赵真真, 张桂菊. 从脾主运化角度论儿童肥胖的治疗[J]. 中国中西医结合儿科学, 2022, 14(3): 257-260.
[9]	赵丹. 学龄前肥胖儿童肠道菌群分布特点及其相关因素分析[J]. 中国中西医结合儿科学, 2021, 13(1): 69-.
[10]	郑博. 白蛋白对新生儿不明原因严重高胆红素血症疗效的研究[J]. 中国中西医结合儿科学, 2020, 12(3): 236-238.
[11]	张银娇, 贾金荣, 龙小慧, 林丽玉, 陈步信, 龙雪微. 穴位贴敷治疗对急性腹泻小儿肠道菌群的影响[J]. 中国中西医结合儿科学, 2020, 12(3): 239-242.
[12]	张建文, 项李娥, 尚莉丽. “肺与大肠相表里”理论与新生儿黄疸诊治相关性探析[J]. 中国中西医结合儿科学, 2019, 11(1): 44-46.
[13]	崔振泽, 徐超, 迟磊. 基于“肺肠理论”和胆汁酸代谢网络探讨定喘汤对呼吸道合胞病毒感染大鼠肠道菌群调节的研究[J]. 中国中西医结合儿科学, 2018, 10(6): 461-465.
[14]	张焱, 袁叶, 刘小渭, 秦艳虹. 茵陈退黄汤治疗新生儿黄疸[J]. 中国中西医结合儿科学, 2018, 10(2): 182-184.
[15]	李方芳. 合生元益生菌冲剂联合复方黄柏液治疗婴幼儿湿疹疗效观察[J]. 中国中西医结合儿科学, 2017, 9(2): 121-123.