长期补充维生素D联合综合行为疗法治疗儿童短暂性抽动障碍的疗效观察

doi:10.20274/j.cnki.issn.1674-3865.2026.03.015

Abstract

Abstract:

Objective To explore the clinical efficacy of long-term vitamin D(VitD) supplementation combined with comprehensive behavioral therapy in the treatment of transient tic disorder(TTD) in children. Methods Totally 150 TTD children who were admitted to the Second Affiliated Hospital of Xinjiang Medical University from January 2023 to June 2024 were selected as study subjects, and they were randomly divided into the control group and the observation group with 75 cases in each group. Both groups received comprehensive behavioral therapy, while the observation group received additional vitamin D intervention. After the treatment course of 24 weeks, the total effective rate of treatment, tic disorder severity, lymphocyte subsets, brain-derived neurotrophic factor(BDNF) and neuron-specific enolase(NSE) levels were compared. Results The total effective rate of treatment in the observation group was 92.0%(69/75), which was higher than that in the control group (80.0%, 60/75), being with statistical difference(P<0.05). After 8 weeks, 16 weeks and 24 weeks of treatment, the Yale global tic severity scale(YGTSS) scores in the observation group were all lower than those in the control group, and there were statistical differences(P<0.05). After treatment, the improvement in lymphocyte subsets in the observation group was better than that in the control group, and the differences were statistically significant(P<0.05). After treatment, the BDNF level in the observation group was higher than that in the control group, while the NSE level was lower than that in the control group, both differences being statistically significant(P<0.05). Conclusion Compared to comprehensive behavioral therapy alone, the long-term supplementation of vitamin D combined with comprehensive behavioral therapy for the treatment of TTD has a higher total effective rate of treatment and more significant improvement in tic symptoms, lymphocyte subsets, and levels of BDNF and NSE, which is worthy of clinical application.

Key words: Transient tic disorder, Vitamin D, Comprehensive behavioral therapy, Lymphocyte subsets, Child

CLC Number:

R748

Xin JIA, Jie ZHANG, Feifei CHEN, Anqi WU, Liying WANG. Study on clinical efficacy of long-term vitamin D supplementation combined with comprehensive behavioral therapy in the treatment of transient tic disorder in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2026, 18(3): 272-276.

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References 29

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组别	n	临床痊愈	显效	有效	无效	总有效
对照组	75	10（13.3）	19（25.3）	31（41.3）	15（20.0）	60（80.0）
观察组	75	20（26.7）	40（53.3）	9（12.0）	6（8.0）	69（92.0）^a

组别	n	治疗前	治疗后8周	治疗后16周	治疗后24周	F值	P值
对照组	75	38.12±6.62	27.60±5.41^a	20.68±3.84^a	16.39±4.74^a	102.859	<0.001
观察组	75	38.55±4.64	22.29±4.65^a	16.11±2.35^a	11.99±4.68^a	102.859	<0.001
t值		0.461	6.446	8.791	5.721
P值		0.646	<0.001	<0.001	<0.001

组别	n	CD4^＋（%）		CD8^＋（%）		CD4^＋/CD8^＋
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	75	29.22±3.54	34.90±3.67^a	33.11±3.10	27.96±2.83^a	0.89±0.13	1.26±0.20^a
观察组	75	29.51±3.24	39.38±3.38^a	33.89±3.82	23.91±3.05^a	0.88±0.15	1.67±0.26^a
t值		0.523	7.776	1.373	8.430	0.436	10.825
P值		0.602	<0.001	0.172	<0.001	0.663	<0.001

组别	n	BDNF		NSE
组别	n	治疗前	治疗后	治疗前	治疗后
对照组	75	2.23±0.49	3.45±0.60^a	22.06±3.21	17.21±2.43^a
观察组	75	2.37±0.52	5.03±0.72^a	22.58±3.51	12.13±1.82^a
t值		1.697	14.600	0.947	14.491
P值		0.092	<0.001	0.345	<0.001

组别	n	治疗前	治疗后	t值	P值
对照组	75	22.11±4.16	23.13±3.63	1.600	0.112
观察组	75	23.10±3.57	34.07±3.21	19.788	<0.001
t值		1.564	19.552
P值		0.120	<0.001

Study on clinical efficacy of long-term vitamin D supplementation combined with comprehensive behavioral therapy in the treatment of transient tic disorder in children

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