儿童肥胖与性早熟共病的文献计量及共享靶点分析

doi:10.20274/j.cnki.issn.1674-3865.2026.04.017

Abstract

Abstract:

Objective To systematically analyze the evolving trends in research on childhood obesity and precocious puberty using bibliometric and bioinformatic methods, and to explore their potential shared molecular mechanisms. Methods The articles on childhood obesity and precocious puberty published between January 2005 and March 2026 were retrieved from the Web of Science Core Collection. VOSviewer and CiteSpace were used to visualize publication trends, collaborations among countries, institutions and authors, as well as keyword evolution. Concurrently, shared targets were identified by integrating the GeneCards, OMIM, and DrugBank databases. A protein-protein interaction network was constructed, followed by GO, KEGG, and DO enrichment analyses. Results A total of 214 articles were included. The annual publication output showed an overall upward trend, with the United States and China being the major contributing countries. Keyword analysis revealed that the research focus in this field had gradually shifted from epidemiological descriptions in the early stage to mechanisms involving metabolic abnormalities, neuroendocrine regulation, and environmental factors. A total of 1 392 shared genes were identified. The protein-protein interaction network suggested that TP53, AKT1, CTNNB1, ESR1, EP300, STAT3, EGFR, and MYC might serve as core nodes. Enrichment analyses indicated that the shared genes primarily involved the biological processes such as transcriptional regulation, hormone response and signal transduction, and were significantly enriched in signaling pathways including PI3K-Akt, MAPK, FoxO, cAMP, and AGE-RAGE. Conclusion Researches on childhood obesity and precocious puberty are shifting from phenotypic association analysis to integrated mechanistic investigation. Core genes such as AKT1, TP53, and ESR1, along with pathways including PI3K-Akt and AGE-RAGE, may play important roles in the comorbidity of these two conditions, providing clues for future mechanistic studies and early intervention.

Key words: Obesity, Precocious puberty, Comorbidity, Bibliometrics, Shared targets, Child

CLC Number:

R585

Peiying XIE, Zhihan YANG, Qiaoying LIU, Fubin SHI, Songxia CAO. Bibliometric and shared target analysis of the comorbidity of childhood obesity and precocious puberty[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2026, 18(4): 358-368.

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References 31

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排名	国家	发文量（篇）	被引频次
1	美国	53	2 509
2	中国	50	748
3	意大利	15	303
4	韩国	12	189
5	英国	11	864
6	巴西	9	214
7	加拿大	8	359
8	土耳其	8	103
9	丹麦	7	396
10	西班牙	6	312

排名	机构	发文量（篇）	被引频次	国家
1	上海交通大学	9	117	中国
2	重庆医科大学	6	276	中国
3	南方医科大学	5	81	中国
4	中山大学	5	76	中国
5	浙江大学	5	78	中国
6	加州大学伯克利分校	5	194	美国
7	圣保罗大学	5	169	巴西
8	布朗大学	5	48	美国
9	中小学教职工保健中心	4	71	中国

排名	作者	发文量（篇）	被引频次	国家	机构	H指数	研究领域
1	Liu Shijian	7	91	中国	上海中医药大学	21	儿科学、内分泌与代谢、公共卫生
2	Lin Cuilan	6	82	中国	中山博爱医院	5	儿科学、内分泌与代谢、营养学
3	Brito Vinicius Nahime	5	79	巴西	圣保罗大学	29	内分泌与代谢、儿科学
4	Fu Junfen	5	79	中国	浙江大学	36	内分泌与代谢、儿科学、营养学
5	Li Xiaoqing	5	90	中国	中国科学院	40	生物化学与分子生物学
6	Latronico Ana Claudia	5	71	巴西	圣保罗大学	52	内分泌与代谢、儿科学、生殖生物学

发表年份	论文题目	第一作者	发文年份	被引频次	来源期刊
2005～2009	儿童肥胖与青春期启动时机	Ahmed ML	2009	299	Trends in Endocrinology & Metabolism
2010～2014	全基因组关联分析揭示青春期身高、时机与儿童肥胖的遗传位点	Cousminer DL	2013	156	Human Molecular Genetics
2015～2019	肥胖与青春期是否存在因果关系？	Reinehr T	2019	215	The Lancet Child & Adolescent Health
2020～2026	中枢神经酰胺介导肥胖致性早熟顶级机制研究	Heras V	2020	77	Cell Metabolism

Bibliometric and shared target analysis of the comorbidity of childhood obesity and precocious puberty

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