ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2011, Vol. 3 ›› Issue (2): 104-106.doi: 10.3969/j.issn.1674-3865.2011.02.004

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Effects of treatment with the GnRH analognes(triptorelin) on girls with idiopathic central precocious puberty

ZHANG Li,LIU Zhengjuan,WANG Yuchuan,et a   

  1. Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China
  • Published:2011-04-25 Online:2019-05-24

Abstract: ObjecticeTo evaluate the effects of the GnRH analognes(triptorelin) on 23 girls with idiopathic central precocious puberty(ICPP).MethodsTotally 23 girls with ICPP received triptorelin therapy for 6 months;before and after the treatment,observe the change of secondary sexual characteristics,volume of the ovary and uterus,bone age,serum level of E2,hormone level of the GnRH stimulating test,and the drug side effects.ResultsAfter 6 months of treatment with triptorelin,the size of breast,uterus and ovary was significantly reduced.The peak levels of serum LH and FSH by GnRH stimulation test and the E2 were also significantly reduced.The ratio of BA/CA decreased,meaning the disrupted maturation of BA.The predicted adult height(PHA) increased from (155.5±0.81)cm to (157.0±0.81)cm,which was better than before treatment.(P<0.01)ConclusionThe treatment with triptorelin can effectively suppress the gonadal axis and sex symptoms,delay the BA maturation,and finally improue the adult height in girls with ICPP.

Key words: Sexual maturation, GnRH, Triptorelin, Children