Abstract:
Objective:Dachaihutang by studying the impact of high fat and cholesterol in the rat model of myocardial tissue and tumor necrosis factor α（TNFα），interleukin6（IL6）protein expression，and further clarify the treatment of high fat Dachaihutang cholesterol mechanisms of disease.
Methods:45 young Wistar rats were randomly divided into normal control group，model group，Dachaihutang 3 groups. Establish control group，given a normal diet and daily normal saline; hyperlipidemia model groups of rats fed with high fat diet modeling; continuous 10 d; experimental section 11 d，Dachaihutang groups according to the amount of drugcontaining crude drug Health and medicine about 0.3 g/mL intervention. Daily living conditions observed in rats，respectively，after modeling 10，20，30 d，measuring weight and statistics. Experimental Section 30 d，within each group to detect the expression of myocardial tissue TNFα，IL6 protein was detected by immunohistochemistry.
Results:Compared with the normal group，model group within hypercholesterolemic myocardium TNFα，IL6 protein expression were significantly increased（P<0.05）. Compared with the model group，within Dachaihutang myocardial tissue TNFα，IL6 protein expression was significantly decreased（P<0.05）.
Conclusion:The highfat highcholesterol in the body to stimulate TNFα，IL6 massive release of cytokines，Dachaihutang can better inhibit TNFα IL6 protein expression of high fat and cholesterol have a certain disease control effect.

Key words: High cholesterol/IL6/TNF&alpha, /Dachaihu Decoction/animal experiments/rat