Abstract: Objective:Da chai hu tang by studying the impact of high fat and cholesterol in the rat model of myocardial tissue and tumor necrosis factor α（TNF α），interleukin 6（IL 6）protein expression，and further clarify the treatment of high fat Dachaihutang cholesterol mechanisms of disease.Methods:45 young Wistar rats were randomly divided into normal control group，model group，Dachaihutang 3 groups. Establish control group，given a normal diet and daily normal saline; hyperlipidemia model groups of rats fed with high fat diet modeling; continuous 10 d; experimental section 11 d，Dachaihutang groups according to the amount of drug containing crude drug Health and medicine about 0.3 g/mL intervention. Daily living conditions observed in rats，respectively，after modeling 10，20，30 d，measuring weight and statistics. Experimental Section 30 d，within each group to detect the expression of myocardial tissue TNF α，IL 6 protein was detected by immunohistochemistry.Results:Compared with the normal group，model group within hypercholesterolemic myocardium TNF α，IL 6 protein expression were significantly increased（P<0.05）. Compared with the model group，within Dachaihutang myocardial tissue TNF α，IL 6 protein expression was significantly decreased（P<0.05）.Conclusion:The high fat high cholesterol in the body to stimulate TNF α，IL 6 massive release of cytokines，Dachaihutang can better inhibit TNF α IL 6 protein expression of high fat and cholesterol have a certain disease control effect.