Abstract:
Objective：To determine the expression of TGF-β1, PAI-1 and MMP-9,and to study their mechanism of action in bronchial asthma airway remodeling in children.
Methods：Forty patients with bronchial asthma in children were given budesonide atomization inhalation treatment and serum were collected and detected before and after treatment for TGF-β1, PAI-1 and MMP-9 levels. At the same time we observed changes in lung function, and compared with the control group (healthy children).
Results：In the serum samples of children with asthma the TGF-β1, PAI-1 and MMP-9 content increased significantly (compared with the control group), and the differences were statistically significant (P＜0.05); at the same time, percentage of FEV1 and PEF decreased; after budesonide inhalation treatment, TGF-β1, PAI-1 and MMP-9 content decreased, and compared with before treatment, there were significant statistical differences (P＜0.05); the percentage of FEV1 and PEF was significantly improved compared with those before treatment, the difference being statistically significant (P＜0.01).
Conclusion：PAI-1, MMP-9 and TGF-β1 changes in children are closely related to bronchial asthma; budesonide inhalation therapy can significantly improve the respiratory condition of the patients, and the possible mechanism may be by reducing the TGF-β1, PAI-1 and MMP-9 level to ihibit airway remodeling and airway inflammation, and achieve the purpose of treating asthma.

Key words: Asthma, TGF-β1, PAI-1/MMP-9, Airway remodeling, Children