Objective：To observe the clinical effect of Yinzhihuang granules, Bifidobacterium tetravaccine tablets and Phenobarbital pills combined with blue light therapy on early neonatal jaundice.

Methods：Totally 192 cases of neonates were randomly divided into 3 groups: group A was given Yinzhihuang granules and Bifidobacterium tetravaccine tablets; group B was added Phenobarbital pills on the basis of group A; group C was given blue light therapy on the basis of group B. The treatment lasted for 5～7 d. Observe the percutaneous bilirubin value changes after treatment.

Results：Comparing the value before and 1~3 days after treatment in the three groups, the difference was of no statistical significance(P>0.05).The difference had statistical significance at 4~7 days after treatment(P<0.05):group C was much lower than group A and B(P<0.01);group B was significantly lower than group A(P<0.05).The total effective rate was 98.4%(63/64) in group C, significantly higher than group A(76.6%,49/64) and group B(81.2%,51/64),the difference being statistical(P<0.017).The total effective rate was not statistically different between group A and B(P>0.017).No adverse reactions occurred in the 3 groups.

Conclusion：Early combination use of Yinzhihuang granules, Bifidobacterium tetravaccine tablets, Phenobarbital pills and blue light therapy has good curative effect in the treatment of neonatal jaundice.