Abstract: Objective To study the treatment effect of albumin combined with blue light phototherapy on neonates with severe hyperbilirubinemia of unknown cause. Methods Totally 60 neonates with severe hyperbilirubinemia of unknown cause treated in our hospital from Dec. 2017 to Dec. 2019 were included as research subjects．A retrospective analysis was performed. The subjects were assigned into observation group(30) and control group(30) according to whether the patients would like to receive albumin treatment on doctors’ advice. The control group was treated only with blue light phototherapy, while the observation group received albumin besides the phototherapy. The following items were compared between the two groups: clinical effect after treatment, and the Creactive protein, total bilirubin and reduction rate of bilirubin before and after treatment, and length of hospital stay. Results The total effective rate of observation group was 93.3％（28/30），which was significantly higher than that of control group was(73.3％, 22/30)（P<0.05）．The total bilirubin, Creactive protein and length of hospital stay in observation group were significantly lower than those in control group, and the reduction rate of bilirubin was significantly higher, the difference being statistically significant(P<0.05)． Conclusion The blue light phototherapy combined with albumin has significant effect in the treatment of neonates with severe hyperbilirubinemia of unknown cause without increasing the potential risk of infection.

Key words: Neonatal jaundice, Albumin, Blue light phototherapy