Abstract:
Objective
To summarize the effect of endotracheal intubation of Calsurf in the traditional way or in the modified way in the treatment of neonatal respiratory distress syndrome(NRDS).
Methods
A total of 96 neonates were selected as the research subjects, who were admitted to Hejian People's Hospital for NRDS between Jan. 2013 to Aug. 2016.Among them,48 neonates were treated with endotracheal intubation of Calsurf in the modified way (modified group) and the other 48 received the intubation in the traditional way (traditional group). The following data were compared between the two groups: the oxygen saturation and heart rate, drug reflux and cynosis of skin during the administration of the medicine, the blood gas result of 2h after treatment, the relief of dyspnea of 12h and 48h after treatment, mechanical ventilation, total time of oxygen use, and the length of hospital stay.
Results
During the treatment,oxygen saturation and heart rate in modified group were obviously higher than those in traditional group, while the incidence of drug reflux and facial cyanosis was much lower, the difference being statistically significant(P<0.05). Two hours after treatment, PaO2 and pH value in modified group were higher than those in traditional group, while PaCO2 was lower, and there was significant statistical difference(P<0.05).The total relief of dyspnea at 12h and 24h after treatment was better in modified group, and the difference was of statistical significance(P<0.05).The time of CPAP and mechanical ventilation and the total time of oxygen use were all shorter in the modified group, the difference being statistical(P<0.05). The length of hospital stay had no statistical difference（P>0.05）.
Conclusion
The treatment with endotracheal intubation of Calsurf in the modified way has less interference in the treatment of neonatal respiratory distress syndrome, which can reduce or even avoid anoxia during the treatment and thus improve the effect of treatment; it is easy to perform and is worth promoting in the neonatal department of primary hospitals.

Key words: Neonatal respiratory distress syndrome, Pulmonary surfactant, Calsurf, Endotracheal intubation, Infant, newborn