Abstract:

Objective
To analyze the effect of sildenafil combined with Calsurf in the treatment of neonatal with persistent pulmonary hypertension.
Methods
A total of 200 PPHN neonates were selected as the research subjects, who were treated in Linxia State People's Hospital from April 2011 to February 2016; the 100 neonates treated from April 2011 to April 2014 were in the control group, while the 100 from May 2011 to February 2016 were included in the observation group. Both groups received positive treatment for primary diseases and support of mechanical ventilation, and intravenous dripping of 20% magnesium sulfate; in addition, the observation group was treated by sildenafil combined with Calsurf. The treatment lasted for 3 days; observe the clinical effect, measure the pulmonary pressure by Doppler ultrasound, and detect the related laboratory indexes in the two groups.
Results
The total effective rate of observation group was 95.0%(95/100), significantly higher than that of control group(65.0%,65/100). The pulmonary pressure after treatment was significantly lower in the observation group, and there was statistical difference(P<0.05).The related blood gas indexes after treatment in the observation group were significantly better than those in the control group(P<0.05).
Conclusion:Calsurf combined with sildenafil for neonates with persistent pulmonary hypertension can obviously improve the clinical symptoms of the neonates; after treatment, the blood-gas-related indexes are decreased, and the Doppler ultrasonography shows a decrease in pulmonary pressure, which promotes the improvement of the disease.

Key words: Neonatal persistent pulmonary hypertension, Calsurf sildenafil, Magnesium sulfate, Mechanical ventilation