Abstract:
Objective
To observe the clinical efficacy of caffeine citrate in very early preterm infants.
Methods
From May 2013 to April 2018, 42 cases of very early preterm infants admitted to Zhengzhou First People's Hospital were selected as the subjects, and they were randomly divided into 21 cases in the observation group and 21 cases in the control group. The control group was treated with aminophylline and a ventilator, and the blood concentration of aminophylline was regularly monitored, so that the blood concentration was maintained at 5 to 10 mg/L. The observation group was treated with caffeine citrate and a ventilator. Observe the clinical efficacy of the two groups, the number of reintubation after treatment, the number of apnea after withdrawal, the ventilation time and the adverse reactions.
Results
The total effective rate of the observation group after treatment was 90.4%(19/21), which was significantly higher than that of the control group(61.9%,13/21), and the difference was statistically significant(P<0.05). There was statistical difference between the two groups in the number of reintubation and the number of apnea after withdrawal, and the ventilation time(P<0.05). After treatment, the indicators of reintubation on the machine in both groups were lower than before treatment, and the difference was statistically significant(P<0.05). The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of ADR between the two groups(P<0.05).
Conclusion
Citrate coffee for an early clinical efficacy is better than that of aminophylline.

Key words: Very early preterm, Caffeine citrate, Mechanical ventilation