Abstract:
Objective
To evaluate the efficacy and safety of recombinant human interferon α-2b(IFN α-2b) spray on herpangina in children, in order to provide scientific evidence for proper administration in pediatrics.
Methods
A total of 122 children with herpangina at Hunan Children's Hospital and Xiangya Hospital were randomly assigned to two groups: the control group(n=61) treated with ribavirin and conventional therapy,and the observation group(n=61) treated with recombinant human IFN α-2b spray and conventional therapy．The clinical efficacy was evaluate．
Results
The total clinical effective rate of the observation group was 80.3%（49/61）,significantly higher than the control group(63.9%,49/61）. The defervescence time，oral and pharynx herpes disappearance time and the eating-recovery time in observation group were significantly shorter than those in control group(P<0.05).During the treatment, there were no adverse drug reactions in both groups.
Conclusion
Recombinant human interferon α-2b spray has significant effect and safety, which can significantly improve the fever course of children with herpangina and shorten the herpes disappearance time and eating-recovery time; there is no adverse reaction.

Key words: Herpangina, Recombinant human interferon α-2b spray, Child