Abstract:
Objective
To defect the expression of TRPC1 in the tissues of hepatoblastoma and to analyze its relationship with clinicopathological features and prognosis.
Methods
The pathological data and clinical data of 16 children with hepatoblastoma(HB) were collected, who underwent hepatectorny in Hunan Children's Hospital from Jan. 2008 to Dec. 2015. The expression of transient receptor potential channel-related protein 1(TRPC1) in HB tissues was detected by immunohistochemistry, its relationship with clinicopathological features(neoplastic tissues and non-neoplastic tissues, the sizes of neoplasm) was analyzed, and its relationship with prognosis was analyzed in the 3 to 5 years of follow-up.
Results
The expression of TRPC1 in the 16 HB children was different, with high expression accounting for 62.5%(10/16) and low expression 37.5%(6/16).The high expression of TRPC1 had statistical difference in the neoplastic and non-neoplastic tissues and in the sizes of neoplasms(P<0.05).The 3-year survival rate was 72.73%(8/11),and the 5-year was 50%(3/6).There was no statistical significance in TRPC1 expression comparing 3-year with 5-year survival rate(P>0.05).
Conclusion
The expression of TRPC1 may be related to the development and progression of HB in children, but it may be irrelevant to prognosis.

Key words: Hepatocastoma, TRPC1, Immunohistochemistry, Clinicopathological festures, Prognosis, Child