Abstract:
Objective
To systematically evaluate the efficacy and safety of Huangqi injection for hypoxic-ischemic encephalopathy(HIE).
Methods
According to the inclusion criteria, random or semi-random controlled trials related to Huangqi injection in the treatment of HIE were searched and selected from PubMed, Embase, Cochrane Library, CBM, CNKI and VIP, etc.(from their inception to November 2016), and relevant literature references were retrieved, supplemented by hand searching of relevant journals and conference papers. Assess the methodological quality of the included trials according to Cochrane Handbook for systematic reviews of interventions. Meta-analysis was performed using the Cochrane Collaboration's RevMan 5.3.
Results
Six randomized controlled trials were included. In the 6 trials, there were 390 cases of HIE, including 220 cases treated by Huangqi injection and 170 cases receiving conventional treatment in the control group. Meta-analysis results showed that conventional treatment combined with Huangqi injection could improve the NBNA［MD=3.61,95%CI(1.86，5.36)］, shorten the average healing time［MD=-1.40,95%CI(-1.66，-1.15)］, and the recovery of clinical symptoms, such as primitive reflex, muscle tension and consciousness was better than the control group, the difference being of statistical significance(P<0.05). No side effects were reported.
Conclusion
Limited evidence indicates that application of Huangqi injection in the treatment of neonatal HIE has a certain curative effect, but because of the low statistical quality of the included trials and the lack of evidence of long-term effect, more well-designed and large-scale randomized controlled trials are needed to verify it.

Key words: Hypoxic-ischemicencephalopathy, Huangqi injection, Systematic evaluation, Evidence-based medicine, Infant,newborn