降钙素原检测在支气管肺炎患儿治疗中的临床价值及与白细胞计数、C反应蛋白的相关性

doi:10.3969/j.issn.1674-3865.2018.02.005

Abstract

Abstract:
objective
To investigate the clinical value of procalcitonin detection in the treatment of children with bronchopneumonia and its correlation with white blood cell count and C-reactive protein by detecting serum procalcitonin in children to guide the rational use of antibiotics.
Methods
A total of 180 children with bronchial pneumonia who were admitted from July 2014 to December 2016 to the Affiliated Hospital of Taicang Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine were selected and randomly divided into control group and observation group with 90 cases in each. The control group was treated routinely, and the observation group was treated with antibiotics based on procalcitonin levels. The body temperature, white blood cell count, C-reactive protein, procalcitonin, antipyretic time, hospital stay, antibiotic use time, and its use rate before and after treatment were observed. The correlation between procalcitonin and leukocyte counts and C-reactive protein was analyzed.
Results
There was statistical difference in body temperature, WBC count, C-reactive protein and procalcitonin in the two groups, which were all lower after treatment(P<0.05). There was no significant difference in the control of body temperature, white blood cells, C-reactive protein and procalcitonin between the treatment group and the control group(P>0.05).There was no significant difference in antipyretic time or hospital stay between the two groups(P>0.05).Antibiotic use time in the observation group was significantly shorter than that in the control group, and the antibiotic use rate was also significantly lower than that in the control group. The difference was statistically significant(P<0.05).Procalcitonin was positively correlated with leukocyte count and C-reactive protein levels, and the difference was statistically significant(P<0.05).
Conclusion
The detection of serum procalcitonin can more effectively guide the use of clinical antibiotics. It has important clinical value in the treatment of children with bronchopneumonia and can effectively avoid clinical abuse of antibiotics.

Key words: Bronchial pneumonia, Procalcitonin, Antibiotics, Children

ZHU Jian，ZHANG Zhiqiao，WANG Wei，LU Haidi，YU Yuhong，MAO Huiqing，WU Xudong，HE Congzhen，MEI Shilan. Clinical value of procalcitonin detection in the treatment of children with bronchopneumonia and its correlation with white blood cell count and C-reactive protein[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2018, 10(2): 106-109.

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Clinical value of procalcitonin detection in the treatment of children with bronchopneumonia and its correlation with white blood cell count and C-reactive protein

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