Abstract: Objective
To observe the clinical effects of Yiqi Huayu Qingre prescription on refractory nephrotic syndrome(RNS) in children.
Methods
A total of 60 cases of RNS enrolled from July 2013 to July 2014 in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine and Children's Hospital of Zhengzhou city were randomly divided into control group(30 cases) and observation group(30 cases). The children were routinely symptomatic treatment in the control group, such as anti-infection, anticoagulation and diuresis, and sufficient prednisone was given(2 mg/kg) to induce remission. The observation group was treated with Yiqi Huayu Qingre prescription on the basis of the treatment for control group, 4 weeks as a course of treatment, for a total of 9 courses. Observe the clinical efficacy and recurrence rate; efficacy indicators:24hUTP,ALB,CHOL,FIB,PT,APT;safety indicators: symptoms and signs of adverse reactions, blood routine examination and hepatorenal function.
Results
The total clinical effective rate of the observation group was 86.7%(26/30), which was better than that of the control group(70.0%,21/30), the difference being statistically significant(P<0.05).After treatment, the recurrence rate in the observation group was 36.7%(11/30), which was significantly lower than that in the control group(70.0%,21/30), the difference being statistically significant(P<0.05). After treatment, the serum albumin, activated partial thrombin time and prothrombin time in the observation group were higher than those before treatment, while 24h protein quantity, total cholesterol and fibrinogen in the observation group were significantly lower, the difference being statistically significant(P<0.05); the observation group was better than the control group in the improvement of the above indexes, the difference being statistically significant(P<0.05). There was no significant difference in such indexes as blood routine, glutamicpyruvic transaminase, glutamicoxaloacetic transaminase, urea nitrogen or serum creatinine between the two groups before and after treatment(P>0.05), and no serious adverse reactions were found.
Conclusion
Yiqi Huayu Qingre prescription can improve the indexes including 24h protein quantity, plasma albumin, blood lipid and hypercoagulability in children, reduce the recurrence rate of refractory nephrotic syndrome in children, and improve the total clinical effective rate. There are no adverse reactions in the clinical observations.

Key words: Refractory nephritic syndrome, Yiqi Huayu Qingre prescription, Children