Abstract:

Objective To explore the risk factors for the chronic development of childhood immune thrombocytopenia.Methods A retrospective selection of 60 children with immune thrombocytopenia admitted to our hospital from January 2017 to June 2020 were divided into a good prognosis group(34 cases) and a poor prognosis group(26 cases) according to the prognosis of the children; both groups of children were given treatment based on bleeding symptoms and treated for 14 days. Analyze and sort the basic clinical data, conduct single factor analysis, and conduct multivariate Logistic regression analysis on factors with statistically significant differences.Results Univariate analysis showed that the proportion of children with a history of infection or vaccination before the onset in the poor prognosis group was significantly higher than that in the good prognosis group, and the peripheral blood ALC level of the children in the poor prognosis group was lower than that in the good prognosis group(P<0.05). The results of multivariate unconditional Logistic regression analysis showed that a history of infection or vaccination before the onset and low ALC levels in peripheral blood were risk factors for the chronic development of children with immune thrombocytopenia(OR=2.428, 2.314, P<0.05).Conclusion A history of infection or vaccination before the onset of the disease and a low absolute level of peripheral blood lymphocytes are likely to have a negative impact on the prognosis of children with immune thrombocytopenia. Clinical attention should be paid to effective prevention and treatment of the risk factors, inhibit the development of the disease, promote the rapid recovery of children, and improve their quality of life.

Key words:

Thrombocytopenia, Immunity, Chronic development, Risk factors, Child