Abstract: Objective To explore the prescription application rule of Professor Qin Man in the treatment of Henoch-Sch  nlein purpura(HSP) in children, and to explore the potential rule of core drug combination, so as to provide evidence and reference for subsequent clinical research of HSP. Methods The clinical prescriptions of Henoch-Sch  nlein purpura treated by Professor Qin Man in the Pediatrics Clinic of Heilongjiang Academy of Traditional Chinese Medicine from June 2020 to October 2021 were collected and screened to establish a database. Data mining and visual analysis were carried out by using the methods of association rules, complex network analysis and cluster analysis, and the application frequency and combination of drugs were summarized.ResultsTotally 82 valid prescriptions were screened out in the database, involving 101 traditional Chinese medicines. The top ten prescriptions in frequency analysis were honeysuckle, licorice, Scutellaria baicalensis, Atractylodes macrocephala, Poria cocos, cicada slough,Dictamnus dasycarpus, buffalo horn, tangerine peel and field thistle. In association analysis, 37 pairs were used more than 58 times, and the top 3 pairs were honeysuckle-Scutellaria baicalensis, honeysuckle-licorice, Scutellaria baicalensis-licorice. Two prescriptions were obtained by cluster analysis: (1)Sophora flavescens, purple grass, Fructus Gardeniae Praeparatus, Schizonepeta tenuifolia, Saposhnikovia divaricata, Dictamnus dasycarpus, buffalo horn, cicada slough, tangerine peel, Pinellia ternata, Atractylodes macrocephala and Poria cocos. (2)Honeysuckle, Scutellaria baicalensis, field thistle, cogon rhizome and Agrimonia pilosa. Conclusion Professor Qin Man combines disease differentiation with syndrome differentiation in the treatment of HSP. The main method of treatment is to clear heat, cool blood and eliminate spots, as well as to clear heat and dryness, invigorate spleen and tonify qi. Prof. Qin Man's treatment and medication rules provide ideas for the subsequent study of traditional Chinese

Key words:

Henoch-Schnlein purpura, Traditional Chinese medicine, Data mining, Medication rule