Abstract: Objective:To observe the effect of IVIG on Toll-like receptor 4 expression of brain tissues exposed on perinatal inflammation.Methods:Forty pregnant SD rats were randomly divided into three groups：intervention group (LPS + IVIG group)(16 rats)，in the 17thday of the conception,give them LPS intraperitoneal injection，with the dose of 350 μg/kg. Give 2 g/kgimmune globulin injection from the female rats' tail vein three hours after the models were made;experimental group (LPS group)(16 rats)，use the same way to make intrauterine infection model of pregnant rats;Control group (NS group)(8 rats)，give intraperitoneal injection of normal saline at the 17thday of gestation. Take intraperitoneal injection of 24 hours (pregnant day 18)，pregnant day 19，pregnant day 21，and the day after birth. Observe the placenta and the point of time of the pathological changes of the brain tissue with hematoxylin-osin staining;compare the weight of the fetal rat; PCR was used to measure the TLR4-mRNA content; immune staining was used to observe each group's TLR4 expression at each time point. Results:In the experimental group, pregnant rats placenta and uterine wall had congestion and edema，and there was leukocyte infiltration，white matter edema and morphology of naive cells，or even visible focal hemorrhage.In experimental group and intervention group offspring weight had varying degrees of loss，there being significant differences compared to control group(P＜0.01).In experimental group and the intervention group's offspring brain，the TLR4-mRNA and TLR4 expression volume are both increased at different time point.Conclusion:Intrauterine LPS infection can lead to fetal brain tissue inflammatory response and giving IVIG timely can reduce the sustained activation of microglia,which inhibits fetal brain tissue inflammation，thereby reducing the extent of brain damage，and achieve the effect of brain protection.