Abstract: Objective：To study the effect of Shenzong granule on micro-inflammation in the rats with nephritic syndrome.Methods：Of 40 SPF male Wistar rats,8 were chosen randomly as the normal control group (group A),and the remained 32 rats were made into nephrotic syndrome models,which were then divided into 4 groups with 8 in each group:model group(B),hormone group(C),Shenzong group(D) and hormone plus Shenzong group(E).Group C，D and E were intervened respectively with hormone,Shenzong granule and hormone plus shenzong granule;detect the level of serum neuclear factor κB（NF-κB）,interleukin 1β(IL-1β),tumor necrosis factor α（TNF-α）,IL-6,and C-reactive protein(CRP).Results：The level of NF-κB,IL-1β,TNF-α,IL-6 and CRP in rats with nephrotic syndrome was significantly reduced in group E,and the difference was statistically significant (P<0.05).Conclusion：The micro-inflammation in rats with nephrotic syndrome is improved by hormone and Shenzong granule. Its working mechanism may be through reducing IL-1β and TNF-α level,the IL-6 secretion,and decreasing the content of CRP and NF-κB,which results in slowing down the reaction of inflammation factors and blocking the inflammation.

Key words: Nephrotic syndrome, Shenzong granule, Micro-inflammation, Rat