Abstract:
Objective
To investigate the clinical features of Langerhans cell histiocytosis(LCH) in children.
Methods
The clinical data of 68 LCH children admitted to Department of Hematology, Hunan Children's Hospital from January 2010 to December 2015 were selected. According to medical history, physical examination, blood routine, liver and kidney function tests, imaging examination and bone marrow cell morphological examination, organ function was evaluated; all cases were divided into three groups. There were 32 cases in group Ⅰ (multi-system high risk), 20 cases in group Ⅱ (multi-system low-risk), and 16 cases in group Ⅲ (single system with multiple bone lesions and limited special parts involved). Totally 65 cases of confirmed LCH children were given LCH-Ⅲ treatment. Three cases of LCH were not given without chemotherapy after diagnosis, among which 1 was neonatal LCH with skin involved, and 2 cases were single lesion of clavicle and treated by focal curettage. Analyze its clinical features, treatment and follow-up results.
Results
In the 68 cases of LCH rash, bone damage, hepatosplenomegaly and other symptoms were more common. Sixty-five patients received chemotherapy, and the total effective rate was 78.46% (51/65) at 6 weeks, and 83.08% (54/65) at 12 months. The follow-up lasted until December 2016, and the cure rate was 58.06% in group Ⅰ,60.00% in group Ⅱ, and 71.43% in group Ⅲ.
Conclusion
LCH children have different clinical manifestations, lesions are widely distributed and are often accompanied by multiple organ dysfunction; therefore, grouped treatment according to clinical characteristics can improve their prognosis, but for those with multiple organ dysfunction, the efficacy needs to be improved.

Key words: Langerhans cell histiocytosis, Clinical features, Children