Abstract: Objective：To explore the differences in clinical characteristics between children with severe nocturnal enuresis(NE) and those with non-severe NE.Methods：The clinical data of children with NE who were admitted to Department of Pediatric Nephrology and Rheumatology,The First Affiliated Hospital,Sun Yat-sen University from July 2014 to August 2023 were retrospectively analyzed.The patients included in the study were divided into severe NE group (n=256) and non-severe NE group (n=62) according to the number of wet nights per week.The clinical characteristics of the two groups were compared.Results：Among the 318 NE children with a median age of 8.0(6.3,10.6) years at visiting the hospital,there were 197 boys.The proportion of the children in severe NE group was higher,who had NE in the first half of the night,large amount of enuresis（P<0.05），difficulty in awakening after bedwetting(P<0.001) and wearing diapers during sleep (P<0.01).Conclusion：Difficulty in awakening is the most common clinical manifestation in children with severe NE.Sleeping state and bladder function should be paid attention to in the children with severe NE in order to take individualized diagnosis and treatment measures.

Key words: Nocturnal enuresis, Clinical features, Difficulty in awakening, Child