Abstract:
Objective
To explore the effect of low molecular weight heparin in different doses on the levels of serum CysC, MMP-9 and β2-MG and the coagulation function in children with Henoch Schonlein purpura nephritis.
Methods
Totally 94 children with Henoch Schonlein purpura nephritis treated in our hospital from November 2015 to April 2017 were selected, and were divided into group A (small dose) and group B(large dose) randomly, 47 cases in each group. Both groups were given basic treatment, and on the basis of that, group A were given subcutaneous injection of 50～100 U/(kg·d) low molecular heparin calcium, and group B were given subcutaneous injection of 150 U/(kg·d) low molecular heparin calcium. Clinical efficacy, the levels of serum CysC, MMP-9 and β2-MG, inflammatory factors, blood coagulation indexes and adverse reactions were compared between the two groups.
Results
Total effective rate of group A was 93.62%(43/47), and there was no significant difference when compared with that of control group(95.74%,44/47)(P>0.05). Serum CysC, MMP-9, and β2-MG levels were significantly lower than those before treatment in the two groups(P<0.05), but there was no significant difference between the two groups(P>0.05). IL-4, IL-6 and IL-8 levels were significantly lower than those before treatment in the two groups(P<0.05), with little difference between the two groups(P>0.05). APTT, Fig and D-D levels were significantly lower than those before treatment in the two groups(P>0.05), and PT level was significantly higher than that before treatment, but there was no significant difference between the two groups(P>0.05). The incidence of adverse reactions in group A (25.5%,12/47) was significantly lower than that in group B (4.3%,2/47)(P<0.05).
Conclusion
Satisfactory results can be achieved in treatment of children with Henoch Schonlein purpura nephritis with different doses of low molecular weight heparin, and subcutaneous injection of low molecular weight heparin is of higher safety.

Key words: Henoch Schonlein purpura nephritis, Low molecular weight heparin, Inflammatory factors, Coagulation function/Adverse reaction, Child