Abstract: Objective:To observe the clinical efficacy of Children＇s Intelligence syrup in the treatment of children with transient tic disorders.Methods:A total of 60 children with transient tic disorders were included in the study, who visited in the Pediatric Department of Qufu Hospital of Traditional Chinese Medicine between Jul. 2016 and Feb. 2018, and they were randomly divided into experimental group and control group, with 30 children in each group. The experimental group took Children＇s Intelligence syrup orally, and the control group took tiapride hydrochloride orally. Two groups were treated for 3 months as a course. The clinical efficacy was evaluated by Yale Globe Tic Severity Scale(YGTSS) with 5 dimensional scores (number, frequency, intensity, complexity and interference). The drug safety was evaluated by Treatment Emergent Symptom Scale(TESS).Results:The total scores of YGTSS of two groups after treatment were significantly lower than those before treatment, there being statistical difference（P<0.05）. The total scores of YGTSS of the experimental group were similar to those of the control group after treatment, and the difference was not statistically significant（P>0.05）. The total effective rate of two groups was similar, the difference being not statistically significant（P>0.05）. The total scores of TESS of the experimental group (2.05±0.18) were significantly lower than those of the control group（13.55±4.82）, there being statistical difference（P<0.05）.The main adverse reactions in experimental group were mild gastrointestinal reactions and those in control group were drowsiness, dizziness, nausea and worse school performance.Conclusion:Children＇s Intelligence syrup has significant effect in the treatment of children with tic disorders, which has fewer adverse reactions and higher safety, so it is worth the clinical promotion and application.

Key words: Tic disorders, Children＇s Intelligence syrup, Clinical study, Children