粉尘螨滴剂联合特布他林、孟鲁司特治疗小儿过敏性哮喘的疗效观察

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2021, Vol. 13 ›› Issue (4): 325-.

Observation on the efficacy of dust mite drops combined with terbutaline and montelukast in the treatment of allergic asthma in children

Objective:To observe the efficacy of dust mite drops combined with terbutaline and montelukast in the treatment of allergic asthma in children.#br# Methods:A total of 80 children with allergic asthma admitted to our hospital from January2018 to January 2020 were selected as the study subjects. According to the random number table, they were divided into the experimental group and the control group with 40 cases each. The control group was treated with terbutaline combined with montelukast, while the experimental group was treated with dust mite dropscombined with terbutaline and montelukast. The therapeutic effect was compared between the two groups; the difference in inflammatory factors(IL-17,IL-10) and immune status(CD4+, CD8+) between the two groups before and 3 months aftertreatment were compared; the incidence of adverse reactions was compared between the two groups within 3months after treatment.#br# Results:The total effective rate of treatment in the experimental group(95.0%, 38/40) was significantly higher than that in the control group(80.0%, 32/40), with a statistically significant difference(P<0.05).After 3 months of treatment, the levels of IL-17, CD4+, and CD8+ in thetwo groups were significantly lower than those before treatment, and they werelower in experimental group than in control group(P<0.05);the level of IL-10 in the experimental group was significantly higher than that in the control group, and it was higher in experimental group than in control group(P<0.05). There was no significant difference in the incidence of adverse reactions during the 3-month treatment between the two groups(P>0.05).#br# Conclusion:Dust mite drops combined with terbutaline and montelukast are effective in the treatment of allergic asthma in children, which can significantly improve the immune function and inhibit the inflammatory response.

Children's Hospital Affiliated to Zhengzhou University，Zhengzhou 450000，China

Online:2021-08-25 Published:2021-12-10

Abstract

Abstract: Objective:To observe the efficacy of dust mite drops combined with terbutaline and montelukast in the treatment of allergic asthma in children.
Methods:A total of 80 children with allergic asthma admitted to our hospital from January2018 to January 2020 were selected as the study subjects. According to the random number table, they were divided into the experimental group and the control group with 40 cases each. The control group was treated with terbutaline combined with montelukast, while the experimental group was treated with dust mite dropscombined with terbutaline and montelukast. The therapeutic effect was compared between the two groups; the difference in inflammatory factors(IL-17,IL-10) and immune status(CD4+, CD8+) between the two groups before and 3 months aftertreatment were compared; the incidence of adverse reactions was compared between the two groups within 3months after treatment.
Results:The total effective rate of treatment in the experimental group(95.0%, 38/40) was significantly higher than that in the control group(80.0%, 32/40), with a statistically significant difference(P<0.05).After 3 months of treatment, the levels of IL-17, CD4+, and CD8+ in thetwo groups were significantly lower than those before treatment, and they werelower in experimental group than in control group(P<0.05);the level of IL-10 in the experimental group was significantly higher than that in the control group, and it was higher in experimental group than in control group(P<0.05). There was no significant difference in the incidence of adverse reactions during the 3-month treatment between the two groups(P>0.05).
Conclusion:Dust mite drops combined with terbutaline and montelukast are effective in the treatment of allergic asthma in children, which can significantly improve the immune function and inhibit the inflammatory response.

Key words: Allergic asthma, Dust mite drops, Terbutaline, Montelukast, Children

LI Yi, SHEN Zhaobo, HUA Li. Observation on the efficacy of dust mite drops combined with terbutaline and montelukast in the treatment of allergic asthma in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2021, 13(4): 325-.

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Observation on the efficacy of dust mite drops combined with terbutaline and montelukast in the treatment of allergic asthma in children

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