Abstract: Objective To evaluate the efficacy and safety of kidney-tonifying in the treatment of bronchial asthma in children in remission period.Methods Cochrane Library, Embase, PubMed, CBM, CNKI, Weipu and Wanfang databases were searched through computers for randomized controlled trials(RCTs) on the treatment of childhood bronchial asthma in remission period, and RevMan 5.3 software was used to evaluate the quality of the included literatures and Meta analysis was made.Results Totally 13 RCTs were finally included, with a total of 1 182 patients, 591 in the experimental group and 591 in the control group. Meta-analysis results showed that kidney-tonifying therapy for bronchial asthma in children could improve the clinical efficacy［Z=6.14,OR=4.75,95%CI(2.89,7.81),P<0.000 01］; the level of peak expiratory flow rate(PEF) of lung function［Z=3.61, MD=0.63, 95%CI(0.29, 0.97), P=0.000 3］; forced vital capacity(FEV1) level in the first second of lung function［Z=4.08, MD=0.21, 95%CI (0.11,0.31),P<0.000 1］; Serum IgA level［Z=6.82,MD=0.22,95%CI(0.16,0.29),P<0.000 01］; Serum IgG level［Z=11.88,MD=1.71,95%CI(1.43,1.99),P<0.000 01］; Serum IgM level［Z=4.70,MD=0.18,95%CI(0.11,0.26),P<0.000 01］; Inflammatory factor IgE level［Z=5.39, MD=-28.13, 95%CI(-38.36,-17.90), P<0.000 01］; the level of inflammatory factor IL-4［Z= 15.22, MD=-5.33, 95%CI(-6.02,-4.64),P<0.000 01］; the level of inflammatory factor IFN-γ［Z=6.62, MD=1.69,95%CI(1.19,2.19),P<0.000 01］. Three studies clearly showed that no obvious adverse reactions occurred, and the rest of the literatures did not mention it. Conclusion Existing data show that the Kidney-tonifying therapy in the treatment of infantile asthma in the remission period is effective in improving the level of lung function, increasing the serum IgA, IgG, IgM, reducing the level of inflammatory factors IgE, and regulating the level of IL-4/IFN-γ.

Key words:

Bronchial asthma；Remission period；Kidney-tonifying therapy；Evaluation of effect, Child