Table of Content

25 February 2022, Volume 14 Issue 1 Previous Issue    Next Issue

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One case of type 1 tyrosinemia with the first-onset manifestation being hypophosphatemia with coagulation and liver dysfunction LIU Suying, MA Hongwei. 2022, 14 (1):  1-2.  Abstract ( 82 )   PDF (753KB) ( 20 )   Save 佝偻病;低磷性佝偻病;范可尼综合征;酪氨酸血症1型 Related Articles | Metrics

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Analysis of anemia in 1 199 infants in Yingkou SUN Linlin 2022, 14 (1):  3-6.  Abstract ( 76 )   PDF (785KB) ( 48 )   Save ObjectiveTo learn about the anemia situation of infants in Yingkou,and to provide scientific basis for prevention and intervention of anemia.MethodsTotally 1 199 infants who underwent regular physical examination from January 2019 to December 2019 were selected as the research subjects.Their blood routine tests were performed to analyze the prevalence rate of anemia in infants of different age groups,and the related influencing factors of anemia were analyzed through questionnaires.ResultsThe incidence rate of anemia in 1 199 infants was 20.5%(246/1 199),with mild anemia being the main type,accounting for 96.7%(238/246).The incidence rate of anemia was the highest in the group aged 6 months to 1 year old(29.3%,136/465),which was higher than that of infants aged 1 to 2 years old and 2 to 3 years old.The incidence rate of anemia gradually decreased with age(P<0.05).Research and analysis showed that the incidence of anemia was related to many factors,including whether the mother had anemia during pregnancy,whether supplementary food was added timely and reasonably,whether she often received parenting guidance,feeding methods within half a year after birth,and whether she had recurrent diarrhea in the past two weeks,and the difference was statistically significant(P<0.05).ConclusionThe keys to preventing infant anemia are to strengthen health care during pregnancy,to prevent gestational anemia and complications,to reduce premature delivery rate,to carry out regular health examination in infants,to popularize knowledge on feeding,to advocate scientific feeding and to add supplementary foods in time. Related Articles | Metrics

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Treatment for children′s chronic aplastic anemia based on "liver producing blood gas" ZHANG Yaru, ZHANG Mengmeng, XING Lulu, ZHAI Wensheng. 2022, 14 (1):  6-9.  Abstract ( 94 )   PDF (811KB) ( 150 )   Save The main symptom of chronic aplastic anemia in children is anemia,and correcting anemia is the key to treatment.The treatment for anemia in traditional Chinese medicine mainly focuses on spleen and kidney.This paper analyzes the biochemistry of blood gas in children with aplastic anemia based on the theory of liver producing blood gas,and puts forward the general principle:spleen and kidney are the foundation,heart and lung are the leading factor,and liver is the motive,cause and mechanism.It analyzes and summarizes the ancient books of traditional Chinese medicine,the commonly used drugs and their mechanism of traditional Chinese medicine.Through regulating liver to generate blood,nourishing liver to store blood,taking liver into consideration first and regulating five internal organs,the gas and blood become sufficient and aplastic anemia can be treated. Related Articles | Metrics

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Effect of drug-containing serum of Li-pi compound preparation on LP,NPY and CCK-8 proteins and genes of rat hypothalamic neuron cells LIU Qiyan, ZHANG Liwen, ZHAN Wei, LI Chun, PANG Ping, GAO Na, PENG Yu. 2022, 14 (1):  10-15.  Abstract ( 81 )   PDF (903KB) ( 178 )   Save ObjectiveTo observe the regulating effects of drug-containing serum of Li-pi compound preparation on LP,NPY and CCK-8 proteins and genes in rat hypothalamic neuron cells and to explore the mechanism of its treatment for anorexia.MethodsFifty rats were randomly divided into control group, low-, medium- and high-dose Li-pi compound preparation group and zinc sulfate group, with 10 in each group. Control group was given equal volume of drinking water by gavage. Zinc sulfate group was given 20 mg/kg zinc sulfate oral solution. Low-, medium- and high-dose Li-pi compound groups were given 2.4,4.8 and 9.8 g/kg of the compound, respectively. Each group was given gavage once a day for 7 days in a row, and the femoral artery blood was collected on the 7th day after gavage to prepare the drug-containing serum. Rat hypothalamic neuron cells were cultured in vitro and identified by MAP2 immunofluorescence. The hypothalamic neurons were randomly divided into control group, low-, medium- and high-dose Li-pi compound preparation group, and zinc sulfate group by CCK-8, and effect on the activity of hypothalamic neuron cells was assessed at 0 h, 2 h,4 h,6 h,8 h,12 h,24 h,36 h and 48 h. After 24 hours of the corresponding serum, the activity of hypothalamic neurons in each drug-containing serum group began to increase and became different. ELISA was used to detect LP, NPY and CCK-8 content in supernatant of hypothalamic neuron cells; Western Blot and real-time fluorescence quantitative PCR were used to detect the relative expression of LP, NPY and CCK-8 protein and genes in hypothalamic neuronal cells.ResultsThe cells were identified as hypothalamic neuronal cells. Compared with the control group, the LP,NPY and CCK-8 content in supernatant of hypothalamic neuron cells was decreased in the supernatant of hypothalamic neuron cells of low-，medium- and high-dose Li-pi compound preparation, and the differences were statistically significant(P<0.05);the relative expression of LP,NPY and CCK-8 protein in hypothalamic neuron cells in Li-pi compound preparation of medium and high doses was decreased, and the differences were statistically significant(P<0.05); the relative expression of LP gene in hypothalamic neuron cells in high-dose Li-pi compound preparation group was decreased, and the difference was statistically significant(P<0.05); the relative expression of NPY and CCK-8 genes in hypothalamic neuron cells in low-, medium- and high-dose Li-pi compound preparation groups was decreased, and the differences were statistically significant(P<0.05).ConclusionLi-pi compound preparation may improve anorexia-related symptoms by comprehensively regulating the expression of LP, NPY and CCK-8 proteins and genes in hypothalamic neurons, but its effect is negatively correlated with dose. Related Articles | Metrics

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Clinical study on treating bronchial asthma at chronic persistent phase in children with Yiqi Huanxiao decoction LI Dongnan, WANG Hai, XING Xinxin, LIU Bonan, WANG Shengnan 2022, 14 (1):  16-20.  Abstract ( 63 )   PDF (807KB) ( 76 )   Save ObjectiveTo observe the clinical effect of Yiqi Huanxiao decoction on bronchial asthma at chronic persistent phase in children and to explore its effectiveness.MethodsTotally 120 children with chronic persistent Qi-deficiency and phlegm-stasis syndrome of bronchial asthma were randomly divided into experimental group and control group,with 60 in each group.The control group was treated with nebulized budesonide combined with montelukast sodium chewable tablets.The experimental group was treated with Yiqi Huanxiao decoction.Record and compare asthma symptom score,C-ACT score,lung function index,serum immunoglobulin level,lung HRCT mosaic sign score,and carry out the statistical analysis.ResultsThere were 7 cases in each group which were lost to follow.The total effective rate in the experimental group was 94.34%(50/53),higher than that in the control group (81.14%,43/53),and the difference was of statistical significance (P<0.05).The asthma symptom score,C-ACT score,FEV1/FVC index,serum immunoglobulin IgA,IgG and IgM level,and lung HRCT mosaic score were significantly lower than those before treatment,and the experimental group was significantly lower than the control group,the difference being statistically significant (P<0.05).ConclusionThe treatment with Yiqi Huanxiao decoction for bronchial asthma at chronic persistent phase in children is superior to traditional western medicine,which has clinical popularization value. Related Articles | Metrics

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Research progress in continuous blood purification therapy for pediatric sepsis XIE Youjun. 2022, 14 (1):  21-25.  Abstract ( 89 )   PDF (835KB) ( 75 )   Save Blood purification is an important adjunctive therapy for pediatric sepsis.Continuous blood purification(CBP) and plasma exchange(PE) are commonly used models in the treatment of pediatric sepsis.The efficacy of PE in the treatment of sepsis in children is currently not supported by large randomized controlled studies.CBP has the advantages of preventing and treating fluid overload,stabilizing hemodynamics,and continuously replacing or protecting damaged organs,so it is often used as the adjuvant therapy for septic shock and sepsis-associated organ dysfunction(SAOD) in children.High-volume hemofiltration is not recommended for CBP dosage,but there is no consensus on the timing of CBP intervention.In this paper,the research progress in CBP in treating sepsis in children was discussed. Related Articles | Metrics

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Research progress on human milk oligosaccharides and intestinal health of infants SHAN Zihong, WANG Shuying, ZHOU Rui. 2022, 14 (1):  25-28.  Abstract ( 79 )   PDF (809KB) ( 7 )   Save Oligosaccharides in breast milk maintain the intestinal health of infants and infants by influencing the composition of the microbial flora in the intestine,resisting the invasion of pathogenic bacteria to intestinal mucosal epithelial cells,and regulating the immune response of the body.Some disordered intestinal diseases,such as necrotizing enterocolitis and diarrhea,can also be effectively prevented and treated.This article mainly describes the research progress on human milk oligosaccharides and infant intestinal health both at home and abroad in recent years,and further explores the correlation between human milk oligosaccharides and infant intestinal health,intending to better guide breastfeeding and provide evidence for the treatment and prevention of related diseases. Related Articles | Metrics

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The clinical significance of D-dimer level in children with severe Mycoplasma pneumoniae pneumonia YUAN Xiaoxu, JIA Chunmei 2022, 14 (1):  29-32.  Abstract ( 76 )   PDF (844KB) ( 55 )   Save ObjectiveAnalyze the clinical value of D-dimer(D-D) level in judging the severity of childhood Mycoplasma pneumoniae pneumonia(MPP) and its significance in early identification of severe MPP.MethodsSelected 255 children with MPP admitted to the pediatric inpatient department of Baotou Fourth Hospital from August 2018 to December 2020,including 80 children with severe MPP(SMPP group) and 175 children with non-SMPP(non-SMPP group).Observe and compare the D-D,peripheral blood white blood cell (WBC),neutrophil percentage (NEU%),high sensitivity C-reactive protein (hs-CRP),ferritin (SF),changes in the levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST) and lactate dehydrogenase (LDH).Results(1) The levels of NEU%,hs-CRP,SF,ALT,AST,LDH，D-D in SMPP group were higher than those in non-SMPP group(P<0.05);(2) Logistic multivariate regression analysis showed that hs-CRP,LDH,and D-D were independent risk factors for predicting SMPP(P<0.01);(3) The area under the ROC curve of hs-CRP,LDH and D-D combined detection is 0.944,95%CI is 0.909～0.979,sensitivity and specificity are as high as 83.80% and 95.40%,respectively;(4)D-D level also has a good ability to predict SMPP with pleural effusion(P<0.01);(5) The level of D-D in children with SMPP in the recovery phase was significantly lower than that in the acute phase.Conclusion(1)The D-D level of children with SMPP increased significantly;(2)Elevated D-D levels can be used as an early predictor of SMPP and complications;(3)The combined detection of the three indicators of hs-CRP,LDH,and D-D has certain guiding value for judging the occurrence of SMPP in children,and is helpful for early identification of SMPP. Related Articles | Metrics

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Diagnostic value of brain ultrasound and magnetic resonance diffusion weighted imaging in preterm infants with white matter injury WANG Huimin, HUO Yaling, WANG Dan 2022, 14 (1):  33-36.  Abstract ( 58 )   PDF (1289KB) ( 75 )   Save ObjectiveTo analyze the characteristics of cranial ultrasound and magnetic resonance diffusion weighted imaging (DWI) in preterm infants with white matter injury (WMI), and to explore their application value in early diagnosis and follow-up of WMI. MethodsThe clinical data of 120 premature infants suspected with WMI in our hospital from January 2018 to February 2020 were retrospectively analyzed, and the results and diagnostic value of craniocerebral ultrasound and DWI were analyzed.ResultsAmong the 120 children, 112 were diagnosed with WMI, 6 with hydrocephalus and 2 with corpus callosum dysplasia. Based on clinical diagnosis, 98 cases (87.50%) of WMI were accurately diagnosed by craniocerebral ultrasound. Taking choroid plexus echo as reference standard and according to the degree of periventricular echo enhancement(PVE) in the first examination, 38 cases were classified into grade Ⅰ, 32 cases into grade Ⅱ, and 28 cases into grade Ⅲ, while 14 cases were missed and misdiagnosed (12.50%). A total of 78 cases (69.64%) of WMI were accurately diagnosed by conventional MRI, including 52 cases of focal lesions, 4 cases of diffuse lesions, 22 cases of periventricular leukomalacia (PVL), and 34 cases of missed diagnosis or misdiagnosis (30.36%). By conventional MRI+DWI，a total of 102 cases (91.07%) of WMI were accurately diagnosed, including 46 cases of focal lesions, 34 cases of diffuse lesions, 22 cases of PVL, and 10 cases of missed diagnosis or misdiagnosis(8.93%).ConclusionBoth craniocerebral ultrasound and DWI can make accurate diagnosis of WMI. Craniocerebral ultrasound is convenient and reproducible, and it is the first choice for preliminary screening and follow-up of WMI. Related Articles | Metrics

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Effect of sensorimotor training on motor skills of children with autism spectrum disorder LYU Nan, YANG Yang, SHANG Qing, WAN Kai, MA Caiyun 2022, 14 (1):  37-41.  Abstract ( 85 )   PDF (813KB) ( 101 )   Save ObjectiveTo explore the effect of sensorimotor training on sensory development and motor skills in children with autism spectrum disorder (ASD).MethodsTotally 60 children with ASD diagnosed in the rehabilitation center of our hospital from January 2018 to October 2019 were randomly divided into treatment group(n=30) and control group(n=30). The control group received routine rehabilitation training, and the treatment group received sensorimotor training in addition to routine rehabilitation training. Before treatment and 3 months after treatment, the children's sensory integration ability (vestibular dysfunction, excessive tactile defense, proprioceptive disorder, in sufficient development of learning ability) was evaluated according to the children's sensory integration ability development scale, and the gross and fine motor abilities were evaluated according to the Peabody motor development scale.ResultsAfter 3 months of treatment, the scores of sensory integration development scale and gross and fine motor function scores of the two groups were significantly higher than those before treatment, and the treatment group was higher than the control group, and there were significant differences(P<0.05).ConclusionSensorimotor training can promote the development of sensory system and improve motor skills in children with ASD. Related Articles | Metrics

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Effect of sensory integration training based on the Denver model on the communication ability of children with autism spectrum disorder aged 2 to 5 years and parenting stress ZHANG Xiaoyu, ZHANG Yanlei. 2022, 14 (1):  41-44.  Abstract ( 59 )   PDF (792KB) ( 128 )   Save ObjectiveTo explore the effect of sensory integration training based on Denver model on the communication ability of children with autism spectrum disorder aged 2 to 5 years and parenting stress.MethodsFrom July 2018 to July 2019, 120 children with autism spectrum disorder aged 2 to 5 years visited our hospital, who were selected as study subjects, and were divided into control group(n=60) and observation group(n=60) according to random number table method. The control group was given comprehensive treatment such as sand game and vitamin D3, and the observation group was given sensory integration training based on the Denver model in addition to the treatment for the control group. After 3 months, ABC，CARS, and ATEC were used to assess the core symptoms; PEP-3 was used to evaluate the communication ability of children; PSI-SF was used to evaluate the parenting stress.ResultsAfter intervention, the scores of ABC, CARS and ATEC and the scores of PSI-SF in the observation group were lower than those in the control group(P<0.05). The score of the third version(PEP-3) scale in the observation group after intervention was higher than that in the control group(P<0.05).ConclusionSensory integration training based on the Denver model can be applied to children with autism spectrum disorder(ASD) aged 2 to 5 years old, which effectively reduces parenting stress by improving their core symptoms and communication ability. Related Articles | Metrics

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Effects of suspension exercise training on gross motor function,balance function and electromyogram in children with spastic cerebral palsy GU Shuli, ZHAO Yangyang, ZHANG Qianqian, LYU Zhengqian, SUO Linjie 2022, 14 (1):  45-48.  Abstract ( 57 )   PDF (808KB) ( 70 )   Save ObjectiveTo explore the effect of suspension exercise training on gross motor function,balance function and electromyography in children with spastic cerebral palsy (cerebral palsy for short).MethodsA total of 89 children with spastic cerebral palsy who were treated in our department from October 2017 to June 2020 were selected as the research objects,and they were randomly divided into a control group of 44 cases and an observation group of 45 cases.The control group received routine rehabilitation training,and the observation group received suspension exercise training on the basis of the control group,and both received continuous treatment for 6 months.The gross motor function,electromyogram,balance function and daily living ability of the two groups were observed.ResultsThe gross motor function D zone,E zone score,balance function score and modified Barthel index score in the observation group were significantly higher than those in the control group,the difference was statistically significant (P<0.05).ConclusionSuspension exercise can significantly improve the gross motor function of children with spastic cerebral palsy,improve the balance ability of children,and at the same time effectively reduce the distribution of EMG on the body surface of children,inhibit the abnormal increase of muscle tension,and improve the ability of daily life. Related Articles | Metrics

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Effect of visual perception training based on the binocular push-pull model on the visual perception, binocular adjustment and vision of 3 to 6-year-old myopic amblyopic children WANG Penglin, YANG Yi, ZHANG Bixiao 2022, 14 (1):  49-52.  Abstract ( 76 )   PDF (785KB) ( 76 )   Save ObjectiveTo explore the effects of visual perception training based on binocular push-pull model on visual perception, binocular adjustment and vision of 3 to 6-year-old children with myopia amblyopia.MethodsTotally 95 children with myopic amblyopia aged 3 to 6 years treated in our department from June 2018 to January 2020 were selected as the research subjects. They were randomly divided into 47 cases in the control group and 48 cases in the observation group. The control group was given conventional training and the observation group was given visual perception training based on binocular push-pull model, both groups were treated for 6 months. The curative effect, visual perception, binocular adjustment function and vision of the two groups were observed.Results(1) Comparison of curative effects: After training, the total effective rate of the observation group was 95.83% (46/48) and that of the control group was 82.98%(39/47). There was no significant difference(P>0.05). (2) Results of visual perception ability: the scores of non-motor visual perception test(MVPT-4), social skill assessment tool(SSAT-Ⅵ) and Canadian job performance scale(COPM) in the observation group were higher than those in the control group, and the difference was statistically significant(P<0.05). (3)Results of binocular adjustment function: The adjustment response(BCC), negative relative adjustment average(NRA), adjustment amplitude(AMP) and adjustment sensitivity(BAF) in the observation group were higher than those in the control group, and the positive relative adjustment average(PRA) was lower than the control group(P<0.05). (4) Vision: Compared with the control group, the observation group had higher DLP, NLP, AC/A,NPC and average diopter(P<0.05).ConclusionVisual perception training based on binocular push-pull model can improve the binocular adjustment function, visual perception ability and vision of 3 to 6-year-old children with myopic amblyopia. Related Articles | Metrics

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Analysis of the risk factors for accidental injuries in children LI Cuilian, LIU Honglin, LIU Ling, XIAO Shufang, XIAO Litao 2022, 14 (1):  53-57.  Abstract ( 98 )   PDF (819KB) ( 92 )   Save ObjectiveTo analyze the clinical characteristics and risk factors of accidental injuries in children and explore targeted preventive measures in order to reduce the incidence of accidental injuries.MethodsA total of 1 002 children with accidental injuries admitted to the emergency department of our hospital from January 2015 to December 2019 were selected as the research subjects.The clinical data of the children were retrospectively analyzed,and 1 002 children admitted to the emergency department during the same period were randomly selected as the control group.ResultsDuring the five-year period,1 002 children with accidental injuries were treated in the emergency department,accounting for 7.52%(1 002/13 326) of the total number of critical illness in children.There were 577 males(57.58%) and 425 females(42.42%).The main types of accidental injuries were poisoning in 478 cases(47.70%),traffic injury in 213 cases(21.26%),falling injury in 137 cases(13.67%),drowning in 46 cases(4.59%),and foreign body injury in 41 cases(4.09%).There were 341 infants(34.03%),383 preschool children(38.22%),197 school-age children(19.66%) and 81 adolescents(8.09%).The occurrence of children′s accidental injury was related to age,single-parent family,guardian′s education level,residence,family harmony and safety education.Logistic regression analysis showed that age,single-parent family,guardian′s education level and safety education were risk factors related to children′s accidental injury,and the degree of family harmony had a certain protective effect on children′s accidental injury.ConclusionThere are regional differences in accidental injuries among children.Poisoning injury is most common in this region,and the age under 6 years old is the high incidence age.Age,single-parent family,guardian′s education level and safety education are the related risk factors of children′s accidental injury. Related Articles | Metrics

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Analysis of the serum 25-hydroxyvitamin D level in 1 338 children in Sanmenxia area CAO Huanzhen, ZHAO Yangyang, KOU Xiaohui, YANG Xiaolin, DU Baoyuan, YAN Jianhua, LI Juan, YUAN Mei. 2022, 14 (1):  58-60.  Abstract ( 57 )   PDF (772KB) ( 82 )   Save ObjectiveTo learn about the serum 25-hydroxyvitamin D level of 0 to 14-year-old children in Sanmenxia．MethodsA total of 1 338 children were chosen, who were treated in Huanghe Sanmenxia Hospital from January 2017 to December 2017.The level of 25(OH)D was determined by high-performance liquid chromatography tandem mass spectrometry.ResultsThe level of 25(0H)D in 1 338 children was (28.17±11.89)μg/L，in which the appropriateness rate was 73.6％(985/1 338).With the increase of the age, the level of vitamin D had a decreasing tendency. The vitamin D level reached the highest level in summer, being (32.65±10.49)μg/L, and the lowest in winter, being (21.32±11.83)μg/L.ConclusionThe level of serum 25(OH)D is good in children aged 0 to 14 years old in Sanmenxia area. The vitamin D level of children changes significantly with the age and season, so they should increase outdoor activities, and vitamin D should be supplemented scientifically and reasonably in accordance with the age and season. Related Articles | Metrics

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Meta-analysis of kidney-tonifying therapy for infantile bronchial asthma in remission period PAN Yushuo, SHU Pei, QU Nini 2022, 14 (1):  61-67.  Abstract ( 82 )   PDF (2756KB) ( 58 )   Save ObjectiveTo evaluate the efficacy and safety of kidney-tonifying in the treatment of bronchial asthma in children in remission period.MethodsCochrane Library, Embase, PubMed, CBM, CNKI, Weipu and Wanfang databases were searched through computers for randomized controlled trials(RCTs) on the treatment of childhood bronchial asthma in remission period, and RevMan 5.3 software was used to evaluate the quality of the included literatures and Meta analysis was made.ResultsTotally 13 RCTs were finally included, with a total of 1 182 patients, 591 in the experimental group and 591 in the control group. Meta-analysis results showed that kidney-tonifying therapy for bronchial asthma in children could improve the clinical efficacy［Z=6.14,OR=4.75,95%CI(2.89,7.81),P<0.000 01］; the level of peak expiratory flow rate(PEF) of lung function［Z=3.61, MD=0.63, 95%CI(0.29, 0.97), P=0.000 3］; forced vital capacity(FEV1) level in the first second of lung function［Z=4.08, MD=0.21, 95%CI (0.11,0.31),P<0.000 1］; Serum IgA level［Z=6.82,MD=0.22,95%CI(0.16,0.29),P<0.000 01］; Serum IgG level［Z=11.88,MD=1.71,95%CI(1.43,1.99),P<0.000 01］; Serum IgM level［Z=4.70,MD=0.18,95%CI(0.11,0.26),P<0.000 01］; Inflammatory factor IgE level［Z=5.39, MD=-28.13, 95%CI(-38.36,-17.90), P<0.000 01］; the level of inflammatory factor IL-4［Z= 15.22, MD=-5.33, 95%CI(-6.02,-4.64),P<0.000 01］; the level of inflammatory factor IFN-γ［Z=6.62, MD=1.69,95%CI(1.19,2.19),P<0.000 01］. Three studies clearly showed that no obvious adverse reactions occurred, and the rest of the literatures did not mention it. ConclusionExisting data show that the Kidney-tonifying therapy in the treatment of infantile asthma in the remission period is effective in improving the level of lung function, increasing the serum IgA, IgG, IgM, reducing the level of inflammatory factors IgE, and regulating the level of IL-4/IFN-γ. Related Articles | Metrics

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Intervention effect of health management with traditional Chinese medicine on children with Qi-deficient constitution(recurrent cold) DUAN Zheng, WANG Zhuo 2022, 14 (1):  68-72.  Abstract ( 75 )   PDF (803KB) ( 698 )   Save ObjectiveTo provide evidence for the clinical effect of health management with traditional Chinese medicine on children with Qi-deficient constitution (recurrent cold). MethodsA total of 68 cases of children with Qi-deficient constitution (recurrent cold) were selected, who were treated in Henan TCM Hospital. Formulate intervention regimen of TCM health management (including diet, living, sports, massage, herbal tea and foot bath), and health education was regularly carried out for the guardians of children. Management time was 4 months, the follow-up period was 1 year, and clinical efficacy was observed before management, and after the 4th month, the 8th month, and the 12th month, including the changes in symptom score of Qi-deficient constitution, the effective rate of constitution improvement and changes in number of colds. Results(1) Through TCM health management, at different time points in a year (after the 4th month, the 8th month, the 12th month), individual symptom score and total score of Qi-deficient constitution were lower than those before management(P<0.001); the number of colds was significantly less than before(P<0.001). (2) After the 12th month, there were 68 cases whose rate of decrease in total score of clinical manifestations of Qi-deficient constitution was no more than 30%, and the effective rate of TCM health management in physical improvement of Qi-deficient constitution was 100%.ConclusionThe effect of TCM health management intervention on children with Qi-deficient constitution is significant, which can effectively improve the Qi-deficient constitution and reduce the incidence of cold. TCM health management intervention for children with Qi-deficient constitution(recurrent cold) has a long-term effect. Related Articles | Metrics

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Clinical effect of Qingyan Lige decoction in the treatment of children with infectious mononucleosis XIE Huandi, YU Minfeng, LONG Tingwei, LIU Shasha, LIU Yingling, SHAN Jinjun 2022, 14 (1):  72-75.  Abstract ( 83 )   PDF (789KB) ( 174 )   Save ObjectiveTo investigate the efficacy and safety of Qingyan Lige decoction in the treatment of children with infectious mononucleosis. MethodsA total of 73 children with infectious mononucleosis(excessive toxic heat syndrome in TCM) were selected，who were hospitalized in the Department of Pediatrics of Shenzhen Hospital of Traditional Chinese Medicine from January 2017 to June 2019, and were given Qingyan Lige decoction orally. On the 5th day of treatment, the self-control study method was used to observe the clinical symptoms and clinical efficacy of the children, and the results of white blood cell（WBC） count, percentage of heterozygous lymphocytes, and EB virus antigen before and after treatment were statistically analyzed.ResultsThe total effective rate of Qingyan Lige decoction was 94.52%(69/73); the peripheral WBC count，the percentage of heterozygous lymphocytes, aspartate aminotransferase, EB virus antigen and whole blood EB virus-DNA were significantly decreased, and the difference was statistically significant(P<0.05). After treatment, the lymph nodes in the liver, spleen and neck were gradually reduced, and the difference was statistically significant(P<0.05).ConclusionThe use of Qingyan Lige decoction in the treatment of children with infectious mononucleosis is safe and effective. Related Articles | Metrics

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Professor Han Xue′s experience in treating refractory Mycoplasma pneumoniae pneumonia in children based on the theory of Qi deficiency LI Gang, HAN Xue 2022, 14 (1):  76-79.  Abstract ( 96 )   PDF (793KB) ( 217 )   Save Refractory Mycoplasma pneumoniae pneumonia（RMPP） is a common disease in children.In recent years,its proportion in children′s community-acquired pneumonia is getting higher and higher.With the abuse of antibiotics,the incidence of refractory Mycoplasma pneumoniae pneumonia is increasing.Clinically it is found that RMPP is increasingly resistant to azithromycin,and its treatment is also quite difficult.In traditional Chinese medicine,it is believed that the children are primarily in deficiency of Qi and are more likely to become ill,and the illness progresses rapidly.Based on this,Professor Han Xue puts forward that the main pathogenesis of RMPP is the deficiency of Qi and the complication of evil.Therefore,the treatment should be focused on the defense of positive Qi with both treatment and nourishment being carried out simultaneously.Later,both Yin and Yang should be strengthened and the evil should be treated in order to achieve good clinical effect. Related Articles | Metrics

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Exploring prescription regularity in treating HSP based on clinical data mining SUN Dongdong, LI Zhaorui, XU Baolin, YU Xintian, HU Honglei, DIAO Juanjuan 2022, 14 (1):  79-82.  Abstract ( 51 )   PDF (779KB) ( 24 )   Save ObjectiveTo investigate the prescription regularity in treating HSP.MethodsThe electronic medical records of 107 HSP child patients in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from May 2016 to September 2020 were collected, and were screened and analyzed which were used to build a prescription database. Frequency statistics method, association rules and cluster analysis(K-means algorithm+regression models) were used to process data mining. Analyze the prescription regularity of traditional Chinese medicine in treating HSP with the help of TCMISS(V3.0) The property and flavor, frequency, meridian distribution, effect and core drug combination of the core drugs were studied.ResultsThere were 16 Chinese herbs with frequency of usage≥20, and the herbs with high frequency of usage included: honey-fried licorice root, rhizoma atractylodis, moutan bark, semen coicis, golden cypress, lithospermum, etc. There were 23 herb pairs with frequency of usage≥30，and the herb pairs with high frequency of usage included rhizoma atractylodis-golden cypress,rhizoma atractylodis-moutan bark-semen coicis, moutan bark-radix paeoniae rubra, etc. Main taste was bitter and sweet, main drug property was cold, and the main meridian distribution was in lung, spleen, liver and heart. ConclusionThe treatment methods for HSP in our hospital were summarized, such as "bitter and sweet law" and "dispelling latent evil". The main drugs are to clear away heat and toxic materials and promote blood circulation and remove blood stasis, and tonifying drugs are used at the same time. Related Articles | Metrics

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Study on the characteristics of Wu Jutong's pediatric medication from the Detailed Analysis of Epidemic Warm Diseases HU Huimin, XI Leiming, PAN Yueli, DIAO Juanjuan. 2022, 14 (1):  83-85.  Abstract ( 88 )   PDF (776KB) ( 13 )   Save Wu Jutong advocated syndrome differentiation of triple energizer in his treatise on the Detailed Analysis of Epidemic Warm Diseases, and formed a syndrome differentiation system of febrile diseases with Wei Qi Ying Xue and triple energizer as the core. In Volume Ⅵ, Jieer Nan, through combination with the theory of febrile diseases, he explained his unique views on pediatric diseases and therapeutic drugs. Wu Jutong believed that children's "pure Yang" was "immature Yang is not sufficient, and immature Yin was not developed". They were more likely to be affected by evil and to change, so the treatment and medication should be cautious. Based on Wu Jutong's understanding of the physiological and pathological characteristics of children, this paper explains the medication characteristics of Wu Jutong in pediatrics from seven aspects: careful selection of drugs, careful use of bitter and cold drugs, more sweet and less sour drugs, skillful use of pungent and temperature drugs, good use of pungent and cool drugs, paying attention to the spleen and stomach, and supplementation of diet, in order to provide reference for clinical medication in pediatrics. Related Articles | Metrics

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An example of drugs pairs commonly used by Professor Jia Liujin in the treatment of pediatric spleen and stomach diseases CAO Xia, ZHANG Yan, JIA Liujin 2022, 14 (1):  86-89.  Abstract ( 95 )   PDF (788KB) ( 7 )   Save As the smallest unit in the compatibility of traditional Chinese Medicine(TCM),drug pair is simple in composition,but it has the basic characteristics of TCM compatibility,and it is also the optimized combination proved by TCM traditional experience.Professor Jia Liujin,one of the first famous Chinese medicine professors in China,emphasizes on syndrome differentiation,promotes combinatorial thinking,and has made good use of combined prescriptions and drug pairs in clinical practice.This article focuses on some drug pairs commonly used by Prof.Jia Liujin in pediatric spleen and stomach diseases:Fructus aurantii and Atractyoldes macrocephalae,Rhizoma atractylodis and Atractylodes macrocephalae,Fructus amomi and Amomum melegueta,Jiao San Xian and Semen raphani,Cao Guo and dried ginger,embodying the characteristics of eliminating and reinforcing,combining tonification with transportation,mixing warming with dispersing,and so on,so that the function of spleen and stomach can be recovered:including taking in and transporting,increasing and decreasing and drying wetness.It can be used to treat anorexia,indigestion,abdominal pain,malnutrition,vomiting and diarrhea.During the treatment,the prescription is made according to the principle and the drugs are used based on the principle,and the effect is significant.The professor′s experience deserves to be summarized and inherited by us in order to give full play to the characteristics of traditional Chinese medicine,improve clinical efficacy,and enhance the cultural confidence of traditional Chinese medicine. Related Articles | Metrics

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Experience in Mugua Niuxi decoction in the treatment of children with Tic disorder HE Xian, SUN Xinyan, ZHANG Heng, ZHANG Baoqing 2022, 14 (1):  89-92.  Abstract ( 200 )   PDF (792KB) ( 9 )   Save Mugua Niuxi decoction,from the Three causes of a disease formula theory,is the main formula of luck in the Liugeng year,which is used in the treatment of excess of Jin luck and insufficiency of Mu luck.This formula is used more frequently in the Liugeng year,and can be used according to the pathogenesis of children in other years.Tic disorder is a common behavioral disorder in children.In recent years,the incidence of it has gradually increased,which seriously affects the daily life of children and their families.TCM treatment for Tic disorder has certain advantages in reducing drug side effects and reducing recurrence rate.Professor Zhang Baoqing specializes in the treatment of children with Tic disorder by using Five Yun Six Qi prescription.This paper introduces Professor Zhang Baoqing′s clinical experience in treating children with Tic disorder by Mugua Niuxi decoction with modification.Professor Zhang Baoqing believes that children′s Tic disorder mainly involves the liver,and is closely related to lung and spleen;the main cause of the disease is "wind",complicated with "phlegm","wetness" and so on,and is closely related to the five Yun and six Qi.Mugua Niuxi decoction,which has the effect of nourishing the blood and softening the liver,relieving wind and stopping spasm,supplemented by moistening the lung and resolving phlegm and strengthening spleen and clearing dampness,is used in the treatment of children with Tic disorder mainly manifested as limb tic,and has achieved great effect. Related Articles | Metrics