Abstract:

Objective To explore the risk factors of death caused by mushroom poisoning in children，in order to make early detection and timely treatment of critical mushroom poisoning，improve prognosis and reduce mortality.Methods A retrospective analysis was performed on 51 children with acute mushroom poisoning admitted to Hunan Children′s Hospital from June 2002 to December 2020，with admission as the starting point of the study and discharge or death as the end point of the study.All cases were divided into survival group and death group，and the study factors included age，gender，hospitalization time，incubation period，complications and organ function indicators.Results Among 51 children with mushroom poisoning，9 died and 42 survived.There was no significant difference in age，gender or incubation period between the two groups (P>0.05).Compared with the survival group，the death group had shorter hospital stay，more damaged organs，and faster disease progression.The organ function damage in the death group was more serious，which was shown by more significant abnormality in aspartate aminotransferase，total bilirubin，direct bilirubin，blood ammonia(NH4)，prothrombin time(PT) and antithrombin Ⅲ(AT3)，international normalized ratio(INR)，creatine kinase isoenzyme(CK-MB)，white blood cell count，platelets and lactate，compared with the survival group，and the differences were statistically significant(P<0.05)，while there was no significant difference in renal function or electrolytes between the two groups.Univariate Logistic regression analysis showed that CK-MB，PT，white blood cell count，NH4，total bilirubin，direct bilirubin，INR，platelets and lactate were all positively correlated with death，while AT3 was negatively correlated with death.Conclusion The increase in CK-MB，PT，white blood cell count，NH4，total bilirubin，direct bilirubin serum，INR，platelets and lactate and the decrease in AT3 are risk factors for death from mushroom poisoning.

Key words:

Mushroom poisoning, Death, Risk factors, Children