ISSN 1674-3865  CN 21-1569/R
主管:国家卫生和计划生育委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

Chinese Pediatrics of Integrated Traditional and Western Medicine ›› 2022, Vol. 14 ›› Issue (4): 344-349.doi: 10.3969/j.issn.1674-3865.2022.04.017

Previous Articles     Next Articles

Meta analysis of Xiaoqinglong decoction in the treatment of infantile bronchiolitis

ZHANG Xiuying, WANG Xuefeng, LIU Qing, XU Wentao, YANG Mengfei, WANG Lei   

  1. The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China

  • Received:2021-11-11 Published:2022-08-25 Online:2022-08-25
  • Contact: WANG Xuefeng,E-mail:lnzywxf@163.com

Abstract:

Objective To systematically evaluate the efficacy and safety of Xiaoqinglong decoction in the treatment of bronchiolitis in children.Methods The databases of CNKI,Wangfang Date,VIP,CBM Embase,Registry Platform and CENTRAL were systematically searched,and the random controlled trials(RCT) of Xiaoqinglong decoction in the treatment of bronchiolitis in children was included,the search time was from January 2006 to December 2020,and the quality of the trial was evaluated by ROB scale recommended by Cochrane and analyzed by RevMan 5.4 statistical software. Results  A total of 15 randomized controlled trials were included,involving 1 270 subjects.The results of Meta analysis showed that Xiaoqinglong decoction could improve the clinical curative effect compared with the western medicine group[RR=1.21,95%CI(1.16,1.27),P<0.000 01].In the aspect of improving the clinical symptoms and signs,such as shortening the antipyretic time,the disappearance time of cough,the disappearance time of asthma,the disappearance time of lung rale and wheezing,the effect of Xiaoqinglong decoction was better than that of the control group,and the difference was statistically significant(P< 0.05).Conclusion Xiaoqinglong decoction can improve the clinical effect,shorten the hospitalization time and improve the clinical symptoms in the treatment of bronchiolitis in children.However,due to the limited number of included studies and the low quality of methodology,it still needs to be confirmed by high-quality and large-sample RCT.



Key words:

Bronchiolitis, Xiaoqinglong decoction, Meta analysis, Children