Abstract: Objective To explore the mechanism of Qingxuan Zhike granules in the treatment of bronchitis based on network pharmacology and molecular docking technology. Methods TCMSP was used to search for the active components of Qingxuan Zhike granules.The Gene Cards database was used to screen for the action targets of bronchitis,and the STRING database and Cytoscape were used to construct the action target network and protein-protein interaction network(PPI) of the components of Qingxuan Zhike granules and bronchitis to find the key action targets.Perl software was used to conduct gene ontology(GO) and genome database(KEGG) pathway enrichment analysis on key action targets.The molecular operation platform software MOE(molecule operating environment) was used for molecular docking .Results The main active components of Qingxuan Zhike granules were stigmasterol,quercetin,locust element,kaempferol,coumarin,licorice flavone,licorice chalcone B,isorhamnetin,luteolin,naringen.The key targets acting on bronchitis were AKT1 ,PPARG ,STAT3 ,ABCA1 ,AHR ,AKR1B1 ,CD163 ,CHUK ,MAPK14 ,ALOX5 .The results of molecular docking verification showed that the core components could fully combine with key targets to play a role.The candidate targets mainly enrich Th17 cell differentiation,Lipid and aerosclerosis,Toxoplastosis,Acute myeloid leukemia,and Adipocytokine signaling pathway.  Conclusion The main components of Qingxuan Zhike granules are quercetin,isorhamnetin,acaricin,kaempferol,etc.By regulating Th17 signal pathway and inflammation signal pathways such as NF-κB signal pathway and AGE-RAGE,they act on MAPK14,STAT3 and CHUK targets,thus playing a role in anti-inflammation,protecting bronchial smooth muscle and improving the clinical symptoms of bronchitis.

Key words:

Bronchitis, Qingxuan Zhike granules, Network pharmacology, Molecular docking, Study on mechanism, Children