Abstract:

Infantile epileptic spasms syndrome (IESS) is a kind of early?onset epileptic encephalopathy, which has a poor clinical outcome and prognosis, and the optimization of the treatment plan for IESS is a hot research topic at present. In recent years, relevant clinical trials have been carried out continuously, and this study summarizes the evaluation indexes for IESS based on the review of literatures: for the evaluation of efficacy, seizure attack is the most basic and direct index, and some of the studies make comprehensive analysis in conjunction with the changes of EEG; regarding the evaluation of EEG, the Krammer score and BASED are commonly used to evaluate the degree of heightened dysrhythmia, and in addition, some of EEG biomarkers are expected to become more standardized evaluation indexes; long?term follow?up needs to focus on the neuromotor development of children, seizure recurrence rate and so on, of which neuromotor development can be evaluated by using scales such as Gesell Scale, Bayley Scale and Griffiths Scale; for the long?term efficacy evaluation after the surgery, the Engel Rating Scale and the ILAE Rating Scale are most commonly used; in the safety evaluation the detection of the corresponding indexes, the reports on adverse events and the records of incidence of adverse reactions are the main indexes; the treatment for IESS with Chinese medicine has certain advantages and potentials, but clinical trials are scarce, and the characteristic indicators of Chinese medicine should be further explored.

Key words: Infantile epileptic spasms syndrome, Evaluation index, Clinical trial, Child