小儿定喘口服液联合西医治疗小儿喘息性支气管炎的临床观察

doi:10.20274/j.cnki.issn.1674-3865.2025.03.010

Abstract

Abstract:

Objective To explore the clinical value of adding Xiaoer Dingchuan oral solution to western medicine treatment in the treatment of children with asthmatic bronchitis. Methods From February 2022 to February 2024, 80 children with asthmatic bronchitis were treated in Zhengzhou People’s Hospital, and they were randomly divided into a control group(40 cases) and an experimental group(40 cases). The control group received conventional western medicine treatment, and the experimental group was treated with Xiaoer Dingchuan oral solution in addition to western medicine treatment. Both groups were treated continuously for 5 days. The total clinical effective rate, the disappearance time of clinical symptoms and signs such as cough and wheezing, the changes in inflammatory factor indexes [interleukin(IL)-4, IL-6, IL-10, interferon-γ(IFN-γ)], and the occurrence of adverse reactions were compared between the two groups. Results After treatment, the total effective rate of the experimental group was 92.5%(37/40), which was higher than 75.0%(30/40) of the control group, and the difference was statistically significant(P=0.034); the disappearance time of cough, gasping, wheezing and coarse moist rales in the experimental group was shorter than that in the control group(P<0.05). The inflammatory factor indexes (IL-4, IL-6, IL-10, and IFN-γ) after treatment in both groups were significantly lower than those before treatment, and the indexes in the experimental group were lower than those in the control group(all P<0.05). The adverse reactions in the control group and the experimental group were mild, and the incidence rate had no statistical difference(P=1.000). Conclusion Compared with the single use of western medicine treatment, the combined use of Xiaoer Dingchuan oral solution and western medicine treatment for children with asthmatic bronchitis has a higher total effective rate, a more significant improvement in the clinical symptoms, and a more obvious recovery of inflammatory factor indexes, and there is no significant increase in the incidence rate of adverse reactions, which is worthy of further exploration and use in clinical practice.

Key words: Asthmatic bronchitis, Inflammatory factor, Xiaoer Dingchuan oral solution, Child

CLC Number:

R725.6

Haifei XIAO, Na WANG. Clinical observation of Xiaoer Dingchuan oral solution combined with western medicine treatment in the treatment of children with asthmatic bronchitis[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(3): 242-245.

Figures/Tables 3

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References 17

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组别	n	显效	有效	无效	总有效
对照组	40	23（57.5）	7（17.5）	10（25.0）	30（75.0）
观察组	40	29（72.5）	8（20.0）	3（7.5）	37（92.5）^a

组别	n	咳嗽	喘息	哮鸣音	粗湿啰音
对照组	40	4.53±0.52	2.85±0.61	3.25±0.62	4.21±0.69
观察组	40	4.23±0.41	2.31±0.52	2.91±0.53	3.95±0.35
t值		2.878	4.251	2.617	2.146
P值		0.005	0.000	0.011	0.036

组别	n	白细胞介素-4				白细胞介素-6
组别	n	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
对照组	40	223.52±19.21	143.26±17.25	27.845	<0.05	218.25±15.26	112.25±10.21	52.643	<0.05
观察组	40	225.32±17.52	135.27±15.28	34.727	<0.05	219.19±14.72	106.23±9.33	59.411	<0.05
t值		0.437	2.194			0.280	2.751
P值		0.663	0.031			0.780	0.007
组别	n	白细胞介素-10				γ干扰素
组别	n	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
对照组	40	172.52±20.01	115.28±19.85	18.164	<0.05	124.32±23.01	175.52±21.82	-14.446	<0.05
观察组	40	171.92±19.34	102.50±18.25	23.360	<0.05	125.26±22.52	192.25±25.32	-17.712	<0.05
t值		0.135	2.998			0.185	3.165
P值		0.893	0.004			0.854	0.002

Clinical observation of Xiaoer Dingchuan oral solution combined with western medicine treatment in the treatment of children with asthmatic bronchitis

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