Abstract:
Objective:
To investigate the effects of ginseng Rg1 on hippocampal neuronal apoptosis and learning ability of neonatal rats with hypoxic-ischemic brain damage.
Methods:
A total of 60 15-day SD rats were chosen and randomly divided into 3 groups: HIBD group, ginseng Rg1 low-dose group and high-dose group, 20 rats in each group. After surgery, ginseng Rg1 was peritoneally injected at 20 μg/g and 10 μg/g every day in the high-dose and low-dose group, while normal saline was injected in HIBD group. The injection continued for 25 days. TUNEL method was used to detect the neuronal apoptosis in hippocampal CA1 area, the learning ability and memory of the rats in each group were tested, and the correct response rate was calculated.
Results:
The number of TUNEL positive cells in hippocampus CA1 area of low-dose group and high-dose group was lower than that of HIBD group, and the number of TUNEL positive cells in hippocampus CA1 area of high-dose group was lower than that in low-dose group(P<0.05). The correct response rate of learning ability and memory test in low-dose group and high-dose group was higher than that in HIBD group. The correct response rate of learning ability and memory test in high-dose group was higher than that in low-dose group(P<0.05).
Conclusion:Ginseng Rg1 can reduce the apoptosis of hippocampal neurons in neonatal rats with hypoxic-ischemic brain damage, and effectively improve the learning ability and memory of these rats.

Key words: Hypoxic-ischemic brain damage, Apoptosis, Ginseng Rg1, Rat