Abstract: ObjectiveTo study the pharmacodynamics and toxicity of Ningdong granule for Tourette syndrome (TS). 
MethodsNingdong granule was given to the mouse by intragastric administration.After that， observe the effect on autonomic activities of mouse，the mouse sleep rate at subthreshold dose of sodium pentobarbital，the special climbing behavior caused by Apomorphine(APO)， the dopamine(DA) content in mouse brain and the acute toxicity.
ResultsBoth the high and low dose of Ningdong granule could obviously inhibit mouse special climbing behavior.High dose could function together with subthreshold dose of sodium pentobarbital to cause mouse sleep.Both the high and low dose could inhibit DA function of mouse substantia nigracorpus striatum，and could obviously shorten mouse continual vertical creeping.The high dose could lower brain DA content.The low dose had the tendency of lowering brain DA content.In the acute toxicity test，the dose corresponding to 77.3 times of children dose was given to the mouse.The mouse lived well.
ConclusionNingdong granule can lower brain DA content.It has the function of sedation，antagonizes creeping caused by APO and helps sleep.Toxicology certifies that it has no obvious toxic action.

Key words: Ningdong granule/Application to treatment；Tourette syndrome/TCM therapy；pharmacology；Toxicology；Animal expertimental