Table of Content

25 February 2009, Volume 1 Issue 1    Next Issue

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Treatment for children pneumonia based on the theory of fever，gloom，phlegm and blood stasis WANG Shouchuan，AI Jun，ZHAO Xia. 2009, 1 (1):  29-32.  Abstract ( 167 )   PDF (378KB) ( 112 )   Save ObjectiveTo prove that children pneumonia can be treated based on the theory of  fever，gloom，phlegm and blood stasis. MethodsProbe into the therapeutic methods of clearing heat，eliminating gloom，dissipating phlegm and removing blood stasis on theory of fever，gloom，phlegm and blood stasis mechanism in children pneumonia.Observe the total effect and changes of symptoms related to the theory of  fever，gloom，phlegm and blood stasis in two groups： one with Qingfei oral liquid and the other with Ribavirin injection；make survival analysis through the method of multicenter，randomized block designed，parallel controlled and blind clinical trial. ResultsThe total effect of test group was much better than that of the control group.The symptoms of fever，gloom，phlegm and blood stasis were common in clinic.Qingfei oral liquid had significant effect in improving symptoms related to fever，gollm，phlegm and blood stais，such as cough，wheezy phlegm，asthma，flaring of nares，sweating，chills，thirsty feeling and cyanosis. ConclusionIt has theory basis of TCM and clinical research that children pneumonia can be treated based on the theory fever，gloom，phlegm and blood stasis and should be widely applied in clinic. Related Articles | Metrics

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Clinical study on the treatment for bronchial asthma in remission stage based on the theory of old phlegm in lung GUO Zhenwu，ZHANG Yafeng，LIN Zhongsi，et al. 2009, 1 (1):  33-36.  Abstract ( 166 )   PDF (455KB) ( 128 )   Save ObjectiveTo probe into the feasibility of clinical treatment for bronchial asthma in remission stage based on the theory of old phlegm in lung. MethodsTotally 200 cases of bronchial asthma in remission stage were divided into two groups，Jinlong Guben mixture of oral treatment and control groups of with 100 cases in each.Clinical treatment lasting two months there was a 2year followup，and observe the effects in patients，and peripheral eosinophil counts，serum immunoglobulin IgG，IgE，T cell subsets and changes in lung function. ResultsThe frequency of recurrence in the treatment group significantly reduced after treatment；eosinophil count decreased significantly；Tlymphocyte subsets of CD8 increased significantly；CD4/CD8 ratio reduced and lung function improved significantly(P<0.05). ConclusionJinlong Guben mixture，which is made based on the theory of old phlegn in lung，has significant clinical effect in treating patients with bronchial asthma in remission stage.Immunologic dysfunction is the cause of recurrent attack of bronchial asthma.The dysfunction can be improved by TCM in the way of consolidating foundation and clearing sputum，which provides throretical basis for the TCM treatment for asthma in remission stage. Related Articles | Metrics

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Clinical effect of Dingchou granule on Tourette syndrome and its mechanism HAN Xinmin，ZHU Xiankang，WANG Minhua. 2009, 1 (1):  37-41.  Abstract ( 291 )   PDF (577KB) ( 116 )   Save ObjectiveTo investigate the clinical effect of Dingchou granule on Tourette syndrome and its mechanism. MethodsA total of 60 patients were randomly divided into 2 groups (treatment group and control group)，30 in each group.The patients in treatment group were administered with Dingchou granule，while the patients in control group were administered with tiapride.We observed tic category，frequency improvement and total effect in both groups before and after the treatment.Mice were randomly divided into 6 groups：normal group，model group，Dingchou granule group with high，moderate，low dose and haloperidol control group，12 mice in each group.We observed motor behavior and improvement of stereotyped behavior in each group 3 weeks after the treatment.HPLC was used to determine the contents of monoamine transmitter in the mice brains of each group. ResultsImprovements in tic category，frequency and total effect in Dingchou granule group were better than those in control group (P<0.05)；Dingchou granule could obviously inhibit motor behavior and stereotyped behavior and decrease the contents of DA and NE，so there was a statistical significance. ConclusionDingchou granule is an effective prescription for Tourette syndrome；decreasing DA and NE contents can be one part of the mechanism of the prescription for tic disorder of mice. Related Articles | Metrics

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Guidelines to Diagnosis and Treatment for Children's Recurrent Respiratory Tract Infection the Delphi evaluation of its indexes and the analysis of the results WANG Lining，WANG Shouchuan，HAN Xinmin，et al. 2009, 1 (1):  42-47.  Abstract ( 380 )   PDF (497KB) ( 130 )   Save ObjectiveTo evaluate and screen the concentration and coordination degree of  the opinions of the experts in TCM pediatrics on the draft frame and diagnosis advice of The Guidelines to Diagnosis and Treatment for Children's Recurrent Respiratory Tract Infection for optimization of this book. MethodsDelphi method was applied to this research.All questionnaires were designed based on the biblimetric research and distributed to more than 40 experts 3 times.The results in the first two times of survey were analyzed. ResultsTotally 47 and 44 valid questionnaires were received in the first and second time respectively.The experts' activity index was 78.3% and 88.0% respectively.The draft of The Guidelines to Diagnosis and Treatment for Children's Recurrent Respiratory Tract Infection was set down.The concentration and coordination degree of the opinions of the experts on this book was obviously high. ConclusionThe experts' activity and professional level is high.The experts are from all over China and express the typical opinions of all experts in this field.The items in the frame of The Guidelines to Diagnosis and Treatment for Children's Recurrent Respiratory Tract Infection are generally recognized，but different opinions on diagnosis standard also exist. Related Articles | Metrics

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Study on the pharmacodynamics of Ningdong granule for Tourette syndrome LI Anyuan，LV Hong，SUN Rong，et al. 2009, 1 (1):  48-50.  Abstract ( 292 )   PDF (316KB) ( 137 )   Save ObjectiveTo study the pharmacodynamics and toxicity of Ningdong granule for Tourette syndrome (TS).  MethodsNingdong granule was given to the mouse by intragastric administration.After that， observe the effect on autonomic activities of mouse，the mouse sleep rate at subthreshold dose of sodium pentobarbital，the special climbing behavior caused by Apomorphine(APO)， the dopamine(DA) content in mouse brain and the acute toxicity. ResultsBoth the high and low dose of Ningdong granule could obviously inhibit mouse special climbing behavior.High dose could function together with subthreshold dose of sodium pentobarbital to cause mouse sleep.Both the high and low dose could inhibit DA function of mouse substantia nigracorpus striatum，and could obviously shorten mouse continual vertical creeping.The high dose could lower brain DA content.The low dose had the tendency of lowering brain DA content.In the acute toxicity test，the dose corresponding to 77.3 times of children dose was given to the mouse.The mouse lived well. ConclusionNingdong granule can lower brain DA content.It has the function of sedation，antagonizes creeping caused by APO and helps sleep.Toxicology certifies that it has no obvious toxic action. Related Articles | Metrics

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Experimental study on influence of  Qingfei oral liquid medicinecontained serum on adhesion and membrane fusion process of respiratory syncytial virus YUAN Bin，LIAO Hui，WANG Shouchuan，et al. 2009, 1 (1):  51-53.  Abstract ( 400 )   PDF (348KB) ( 100 )   Save ObjectiveTo study the inhibition effects of Qingfei oral liquid medicinecontained serum on adhesion and membrane fusion process of respiratory syncytial virus. MethodsUsing the method of temperature conversion，we added Qingfei oral liquid medicinecontained serum during adhesion period(before temperature conversion) and invasion period(after temperature conversion) respectively.Monitor virus inhibition rates and average A of the two periods，observe the influence of Qingfei oral liquid medicinecontained serum on adhesion and membrane fusion process of respiratory syncytial virus. ResultsNo significant differences were found on the average A between Qingfei oral liquid medicinecontained serum group and virus control group before temperature conversion experiment.After the temperature conversion，virus inhibition rates of Qingfei oral liquid medicinecontained serum group increased，the average A increasing obviously.Differences were significant before and after temperature conversion experiment. ConclusionThe antiviral effect of Qingfei oral liquid medicinecontained serum mainly embodies on the membrane fusion and invasion phases  after adhesion process of respiratory syncytial virus. Related Articles | Metrics

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An analysis of the third turn of questionnaires on the study of methods for effect evaluation of TCM treatment for children virus pneumoni ZHAO Xia，WANG Shouchuan，LI De. 2009, 1 (1):  54-57.  Abstract ( 218 )   PDF (380KB) ( 136 )   Save ObjectiveTo study the methods for evaluating effect of TCM treatment for children virus pneumonia. MethodsOn the basis of the outcome of analysis made on the previous two turns of questionnaires，the third turn of questionnaires was prepared to investigate the effect evaluation method of TCM treatment for children virus pneumonia.They were distributed to 30 experts in this field all over the country.The questionnaire was analyzed with the method of Delphi Measurement. ResultsChest Xray，symptoms，body temperature，lung auscultation and main symptoms' score reduction were very important in disease effect evaluation，the mean number more than 1.5，the ratio of full score higher than 0.5 and the coefficient of variation less than 0.4；cough，lung auscultation，chest Xray and so on were main components in the syndrome，and the mean number，the ratio of full score and the coefficient of variation was 2，1and 0 respectively；dyspnea，lung auscultation and chest Xray were main final result index and the ratio of full score and the coefficient of variation was 1 and 0 respectively. ConclusionChest Xray，symptoms，body temperature and lung auscultation are very important in disease effect evaluation；cough and lung auscultation are main components in the syndrome；dyspnea and lung auscultation are main final result index. Related Articles | Metrics