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25 April 2009, Volume 1 Issue 2 Previous Issue    Next Issue

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Effect of external application of Xiaoji powder on the gastrointestinal motility GE Meifei，WANG Lanqing.Department of Pediatrics，TCM Hospital in Qingdao,Qingdao 266033,China 2009, 1 (2):  130-132.  Abstract ( 239 )   Save ObjectiveTo explore the effect of external application of Xiaoji powder on the gastrointestinal motility. Methods①Thirty mice of 1822 g were divided into 3 groups.Measure their length and the distance from forefront of the carbon at the end to the cardia,and calculate the percentage of the distance /the fulllength,that is,the subrate promoter.②Take a section of the jejunum (about 3 cm),ligate both ends of the intestine with wire,tie one end to the ventilation hook,put it in the Michael's bath trough filled with Tyrode solution,access to the oxygen with 5% CO2,and control water bath temperature at （35.0±0.1）℃.The other end lines in the the transducer,which had about 2 g load,and connect with recording devices to observe the normal movement of intestinal smooth muscle.And then, feed the mice with medicine according to three different orders and PsG its waveform.③ Wistar rats 30.Experiment group: 10,with external application of Xiaoji powder on Shenque Point and Zhongwan Point of rats.Spleen deficiency group: 10,making models and gastrointestinal bioelectric detection at the same period with experiment group,but without any drug.Healthy rats group (referred to as the blank group): normal rats 10,with the gastrointestinal bioelectric detection at the same period with the above two groups. Results①Five days after abdominal application of Xiaoji power(0.1 g per mouce),the medicine showed a very significant effect in enhancing gastrointestinal propulsive function.② Xiaoji powder not only had relaxing effect on the normal smooth muscle in vitro,but also had a strong spasmolytic effect on acetylcholine,green bariuminduced spasm of intestinal smooth muscle.The experiment was based on 10 μg atropine sulfate as a positive control to carry out control experiments.It showed the graphics of atropine sulfate in spasmolytic role.③Xiaoji powder navel paste therapy played a positive role in adjusting the gastrointestinal electric disorder caused by deficiency of spleen Qi，and could restore it to its normal state. ConclusionXiaoji powder is expected to be a new type of external application of traditional Chinese medicine in gastrointestinal motility. Related Articles | Metrics

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Insulin receptor substrate2 expression levels in pancreas of intrauterine growth retarded rats LI Yao，XIN Ying. 2009, 1 (2):  133-135.  Abstract ( 301 )   Save ObjectiveTo observe the expression of insulin receptor substrate2 （IRS2）on intrauterine growth retardation（IUGR），and to investigate molecular mechanisms for insulin resistance in IUGR rats. MethodsAn IUGR animal model was established by protein malnutrition during pregnancy.Study the expression of IRS2 by immunohistochemistry at newborn，at 3 weeks and 8 weeks respectively on control group fed with common diet and IUGR lowprotein diet group. ResultsThe level of protein of IRS2 at newborn，3 weeks and 8 weeks of IUGR was significantly lower than that of control group respectively. ConclusionIUGR can induce the obstacle of signal transduction and effecter molecule by impacting on IRS2，which might be one of the molecular mechanisms of IUGR with insulin resistance at adult. Related Articles | Metrics

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Qingre Huazhi granule for retention of food belonging to windheat syndrome in children: an observation of 905 cases LIU Jianzhong*，LIU Shutang，XIAO Mingzhong,et al.*Hubei 2009, 1 (2):  136-139.  Abstract ( 409 )   Save ObjectiveTo observe the clinical efficacy of Qingre Huazhi granule to cure the children retention of food belonging to windheat syndrome， and investigate its effects on the level of animals gastrointestinal hormones. MethodsTotally 905 cases of retention of food were randomly divided into observation group and the control group in clinical research. The children of observation group orally took the Qingre Huazhi granule；the children of control group orally took Jianer Qingjie liquid. The gastrointestinal hormones of dyspeptic disease mice were researched in animal experiment. ResultsMany clinical studies had shown that the rate of cure, the rate of significance and the total effective rate of Qingre Huazhi granule was 63.31%, 23.79% and 87.10%，respectively. The rate of cure, the rate of significance and the total effective rate of Jianer Qingjie liquid was 46.07%, 28.57% and 74.64%，respectively. The comprehensive efficacy, cure rate and total effective rate in the observation group were better than those of the control group, which had significant differences in statistics.Animal experiments showed that particles could improve the content of motilin (MOT) and gastrin (GAS) in blood and small intestine tissue of mice, and could reduce the level of somatostatin (SS), but the effect on vasoactive intestinal peptide was not obvious. ConclusionIn our study, the Qingre Huazhi granule's clinical efficacy is safe and reliable， and can obviously improve the gastrointestinal peristalsis of the children retention of food belonging to windheat syndrome. Related Articles | Metrics

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The curative effect of the treament for recurrent respiratory tract infection in children with plant polysaccharide oral liquid LI Ming，HOU Xiaoli，FAN Wenjing. 2009, 1 (2):  140-143.  Abstract ( 285 )   Save ObjectiveTo observe the control efficiency of the plant polysaccharide oral liquid for the children with recurrent respiratory tract infection. MethodsNephelometry and indirect immunofluorescence assay were used to check out the activity of the serum immune globulin and the T cell subsets in the 102 reinfected children who were treated in Zhongshan Hospital affiliated to Dalian University from 200707 to 200807.A total of 102 cases of reinfected children were randomly divided into two groups,plant polysaccharide oral liquid treatment group (62 cases) and transfer factor oral treatment group (40 cases).Both of the two groups were treated for 3 months.Prepare 40 cases of healthy children as the healthy control group.Follow up the 102 cases for 6 and 12 months. ResultsBefore the treatment,each of functional parameters of the immune function of the reinfected children was significantly lower than the healthy control group.After 6 months` plant polysaccharide oral liquid treatment,the functional parameters were all put back or markedly improved,with the total effective rate of 98.4%.Meanwhile，after 12 months` plant polysaccharide oral liquid treatment,the effect was significantly higher than transfer factor oral treatment group,the difference being statistically significant (P<0.05). ConclusionRecurrent respiratory tract infection in children is complicated with the existence of T cells and B cells immune deficiency.Plant polysaccharide oral liquid has a wide immune activation for both the shortterm and longterm recurrent respiratory tract infection. Related Articles | Metrics