Abstract:
Nuclear factor kappa B is a transcription-promoting protein, which regulates the gene expression of inflammatory mediators and function of many kinds of cells in airway. It is a core element in the research of asthma prevention and treatment. NF-kappa B can regulate the production of proinflammatory factors after activation,and participates in the transcription of a variety of proinflammatory and chemokine genes. I kappa B is one of the NF- kappa B signal pathways and is inactive in the cytoplasm. The phosphorylation arises after I kappa B is activated by external stimuli, and then NF- kappa B is activated. Tumor necrosis factor α stimulates I kappa B kinase α to enter into the nucleus, which then regulate the expression of specific NF-kappa B response gene.

Key words: Asthma, Airway smooth muscle, Nuclear transcription factor kappa B, Children