Abstract: Erdi Yishu soup is made based on many years of clinical experience of Professor Chen Zhu and the characteristics of the contemporary diet of children,which is used for the treatment of precocious puberty(PP) in girls with yin deficiency of kidney and liver and spleen deficiency with dampness and heat syndrome,and has achieved significant effect.In this paper,we comprehensively analyze Erdi Yishu soup from the four dimensions of property,specific part,tendency and syndrome.The property of Erdi Yishu soup is sweet,bitter,cold and cool:the bitter and cold is for reducing fire,the hot and cold for inhibiting,and the sweet and cold for generating fluid,which can solve the problem of deficiency of yin and excess of fire and excessive dampness and heat inside.The specific part is in the kidney,liver and spleen,which can relieve yin depression in the liver and kidney,and solve the trouble of dampness in the spleen.The tendency is upwardly declaring and dispersing,focusing on the middle jiao to remove dampness,clear heat and regulate the middle,and downwardly tonifying the yin of the liver and kidney,so that the upper,middle and lower jiao can be treated together,which results in the coordination of zang fu and smooth flow of yin fluids of qi and blood.The syndrome is the yin deficiency of the liver and kidney and spleen deficiency with dampness and heat.The modern pharmacological mechanism of Erdi Yishu soup for the treatment of precocious puberty includes such aspects as inhibition of central nervous system,regulation of sex hormones,and reduction in glucose and lipid.This paper analyzes the syndrome of the formula of Erdi Yishu soup to provide reference for its clinical application and modern development.

Key words: Precocious puberty, Erdi Yishu soup, Analysis of the formula；Girl child