维生素D与儿童急性炎症合并贫血的相关性研究

doi:10.20274/j.cnki.issn.1674-3865.2026.01.015

Abstract

Abstract:

Objective To explore the expression level and correlations of vitamin D in children with acute inflammation complicated by anemia, so as to provide a basis for the clinical prevention and treatment of this condition in children. Methods The children aged 1-14 years who were treated at the Department of Pediatrics of the First Affiliated Hospital of Shihezi University between October 2023 and March 2025 were prospectively recruited as the research subjects. Among them, there were 100 cases in the group of acute inflammation complicated by anemia, 100 cases in the group of acute inflammation without anemia, and 100 cases in the healthy control group. The clinical data and laboratory parameters of the three groups of children were measured and compared. Multivariate linear regression analysis was employed to explore the influencing factors for the occurrence of acute inflammation complicated by anemia in children and to investigate the association between 25-hydroxyvitamin D and acute inflammation complicated by anemia in children. Results The levels of 25(OH)D and Hb in the group of acute inflammation with anemia and the group of acute inflammation without anemia were lower than those in the healthy control group, and the differences were statistically significant(P<0.05). Comparing the group of acute inflammation with anemia with the group of acute inflammation without anemia, the differences in the levels of CRP, PCT, and 25(OH)D were statistically significant. When the above indicators were introduced into the multivariate Logistic regression analysis model, the analysis results showed that low 25(OH)D level, and high CRP and PCT levels were risk factors for the occurrence of acute inflammation with anemia in children, and the thresholds of the three were 48.25 μg/L, 27.76 ng/L, and 0.91 mg/L, respectively; their AUCs were 0.850, 0.705, and 0.754, respectively, and the area under the curve of the combined application was 0.913, which indicated that the diagnostic efficiency of the combined application of the three was higher. Conclusions Low vitamin D levels and high inflammatory mediator levels are risk factors for the incidence of acute inflammation complicated by anemia. Vitamin D supplementation may contribute to reducing the incidence of acute inflammation complicated by anemia.

Key words: Acute inflammation, Anemia, Vitamin D, Child

CLC Number:

R725.5

Yawen SONG, Bo CHEN. Research on the association between vitamin D and acute inflammation complicated by anemia in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2026, 18(1): 77-81.

Figures/Tables 5

Table 1

Table 2

Comparison of inflammatory indicators in acute inflammation with anemia group and acute inflammation without anemia group( x ± s )"

组别	n	C反应蛋白（mg/L）	白细胞介素-6（μg/L）	降钙素原（ng/L）	中性粒细胞计数（ $× 109$ /L）	白细胞计数（ $× 109$ /L）
急性炎症合并贫血	100	33.00±28.54	27.27±24.55	1.47±1.44	5.69±3.89	11.29±4.32
急性炎症不伴贫血	100	12.46±7.81	26.37±24.96	0.51±0.59	4.81±2.21	9.78±4.17
t值		6.942	0.258	6.154	1.960	2.496
P值		<0.001	0.797	<0.001	0.052	0.013

Table 2

Table 3

Table 4

Fig. 1

References 31

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组别	n	血红蛋白(g/L）	25-羟维生素D(μg/L)
健康对照组	100	112.79±3.90	66.07±9.29
急性炎症不伴贫血组	100	107.52±5.17^b	53.39±7.34^b
急性炎症合并贫血组	100	102.99±9.76^ab	38.37±12.97^ab
F值		52.65	187.09
P值		<0.001	<0.001

因素	β值	SE	Wald	P值	OR值	95%CI
常数	2.781	1.223	5.174	0.023	-	-
C反应蛋白	0.065	0.018	13.415	<0.001	1.068	1.031～1.106
降钙素原	1.440	0.414	12.113	0.001	4.219	1.876～9.492
25-羟维生素D	-0.120	0.024	26.214	<0.001	0.886	0.847～0.928
白细胞计数	0.088	0.047	3.440	0.064	1.092	0.995～1.198

指标	曲线下面积(95%CI)	阈值	灵敏度	特异度	约登指数
25-羟维生素D	0.850（0.794～0.906）	48.25 μg/L	0.83	0.73	0.56
降钙素原	0.754（0.684～0.823）	0.91 mg/L	0.53	0.96	0.49
C反应蛋白	0.705（0.629～0.782）	27.76 ng/L	0.52	0.97	0.49
联合应用	0.913（0.871～0.954）	0.49	0.79	0.92	0.71

Research on the association between vitamin D and acute inflammation complicated by anemia in children

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