健脾益气膏治疗小儿厌食(脾胃气虚证)的疗效观察

doi:10.20274/j.cnki.issn.1674-3865.2025.06.003

Abstract

Abstract:

Objective To explore the clinical effects of Jianpi Yiqi (tonifying spleen and benefiting qi) ointment in the treatment of pediatric anorexia (spleen stomach qi-deficiency syndrome). Method One hundred children with anorexia(spleen and stomach qi-deficiency syndrome) admitted to the Pediatric Department of Jingzhou Hospital of Traditional Chinese Medicine from January 2023 to February 2024 were selected as the research subjects, and they were randomly divided into a control group and an observation group, each consisting of 50 cases. The control group was treated with oral administration of Xingpi Yanger granules, while the observation group was treated with oral administration of Jianpi Yiqi ointment. The total effective rate of treatment, the excretion rate of urinary D-xylose, the ratio of salivary amylase activity, the levels of gastrin, motilin and neuropeptide Y, the improvement in symptom scores, and the body weight and height before and after treatment were observed and compared between the two groups. Results The total effective rate of treatment for children with anorexia(spleen and stomach qi-deficiency syndrome) in the observation group was 98.0%(49/50), significantly higher than that in the control group (84.0%, 42/50), with a statistically significant difference(P<0.05). After treatment, the urine D-xylose excretion rate, salivary amylase activity ratio, gastrin level, motilin level, and neuropeptide Y level in the observation group were higher than those in the control group, with statistically significant differences(P<0.05). After treatment, the symptom scores(food intake, appetite, and eating time) in the observation group were lower than those in the control group, with statistically significant differences(P<0.05). There was no statistically significant difference in body weight or height between the two groups before and after treatment(P>0.05). Conclusion Jianpi Yiqi ointment in the treatment of children with anorexia(spleen and stomach qi-deficiency syndrome) can significantly improve the therapeutic effect on the children, significantly improve a series of clinical indicators in them, and promote the relief of the clinical symptoms.

Key words: Anorexia, Spleen and stomach qi-deficiency syndrome, Jianpi Yiqi ointment, Child

CLC Number:

R442.1

Qimin TANG, Yishi TU. Observation on the curative effect of Jianpi Yiqi ointment in treating anorexia(spleen and stomach qi-deficiency syndrome) in children[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(6): 472-476.

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References 30

[1]	田真. 益气健脾开胃消食汤治疗小儿脾胃气虚型厌食症31例[J]. 中国中医药科技, 2023, 30(2): 380-382.
[2]	Frintrop L, Trinh S, Seitz J, et al. The role of glial cells in regulating feeding behavior: potential relevance to anorexia nervosa[J]. J Clin Med, 2021, 11(1): 186.
[3]	穆冰燕, 孙丽平. 中药治疗小儿厌食的用药规律分析[J]. 中国医药导报, 2021, 18(30): 154-157.
[4]	王海生,李昕,付佳佳,等. 神经性厌食合并肝损害肠外营养治疗1例[J]. 中华健康管理学杂志,2024,18(2):144-145.
[5]	任翔宇, 葛慧, 赵纳, 等. 清胃健脾丸治疗小儿厌食的活性成分及药理作用机制研究[J]. 世界中医药, 2024, 19(20): 3067-3076.
[6]	Pruccoli J, Barbieri E, Visconti C, et al. Refeeding syndrome and psychopharmacological interventions in children and adolescents with Anorexia Nervosa: a focus on olanzapine-related modifications of electrolyte balance[J]. Eur J Pediatr, 2024, 183(4): 1935-1941.
[7]	邵亚新, 申慧贞, 杨燕. 杨燕运用温运理气法治疗小儿厌食临床经验[J]. 北京中医药, 2024, 43(4): 385-387.
[8]	陈斐斐, 徐辉甫, 鲁芳. 补肾健脾膏方治疗脾虚厌食症及其对中医证候和生长发育的影响[J]. 长春中医药大学学报, 2024, 40(11): 1220-1223.
[9]	高文侠, 葛小栋, 王建桥, 等. 六君子汤加味联合甲地孕酮治疗结肠癌手术化疗后厌食症的疗效观察[J]. 安徽医药, 2024, 28(8): 1659-1662.
[10]	马融, 胡思源, 王俊宏, 等. 小儿厌食中药新药临床试验设计与评价技术指南[J]. 药物评价研究, 2015, 38(3): 244-250.
[11]	徐荣谦, 袁美凤. 小儿厌食症的诊疗标准[J]. 中国临床医生, 1999, 27(3): 12.
[12]	仇雅朋, 李晓璇, 蔡秋晗, 等. 小儿厌食症临床试验设计与评价技术要点的文献研究[J]. 天津中医药, 2020, 37(5): 559-564.
[13]	冯硕, 池莲, 周义山, 等. 开璇玑联合按弦搓摩复式推拿配合中药治疗小儿厌食症临床研究[J]. 山东中医杂志, 2024, 43(10): 1112-1117.
[14]	林靖茹, 罗玉君. 林季文治疗岭南地区小儿厌食症经验[J]. 中国中医药图书情报杂志, 2024, 48(6): 313-316.
[15]	L'Huillier C, Jarbeau M, Achamrah N, et al. Glutamine, but not branched-chain amino acids, restores intestinal barrier function during activity-based anorexia[J]. Nutrients, 2019, 11(6): 1348.
[16]	胡娟, 刘莉, 米本中, 等. 四磨汤对幼龄小鼠厌食症模型的影响[J]. 中药药理与临床, 2019, 35(6): 27-31.
[17]	吴洪兰, 徐梦楠, 孙涛. 老年厌食症评估与治疗研究进展[J]. 现代消化及介入诊疗, 2024, 29(7): 873-876.
[18]	张一樱. 健脾和胃汤治疗儿童厌食症的疗效观察及其对血清LEP、CCK的影响[J]. 中国中医药科技, 2023, 30(3): 491-493.
[19]	何岳珍, 陈静, 史正刚, 等. 基于“脾失健运” 探讨运脾法调节肠道菌群治疗小儿厌食症[J]. 中国中医药信息杂志, 2023, 30(8): 14-17.
[20]	Bertrand V, Tavolacci MP, Bargiacchi A, et al. Analysis of feeding and eating disorders in 191 children according to psychiatric or gastroenterological recruitment: the PEDIAFED cohort study[J]. Eur Eat Disord Rev, 2024, 32(3): 589-605.
[21]	王馨禾, 孙丽平. 孙丽平教授辨体质治疗小儿厌食症临床经验[J]. 中国中西医结合儿科学, 2024, 16(4): 363-366.
[22]	蒋会莉,刘钇彤,付珊珊,等.琚玮教授从脏腑辨证治疗小儿厌食经验[J].中国中西医结合儿科学,2024,16(4):366-368.
[23]	范涛, 李梦. 醒脾消食汤治疗小儿厌食症的疗效及对体内微量元素和血清胃泌素、神经肽Y水平的影响[J]. 河北中医, 2023, 45(10): 1663-1665.
[24]	刘畅, 岳双, 郭紫云, 等. 运脾膏膏摩治疗小儿厌食症脾胃气虚证临床观察[J]. 河北中医, 2023, 45(9): 1481-1485.
[25]	孔亚如, 施春华, 秦浩峰. 认知矫正疗法辅助治疗神经性厌食症研究进展[J]. 新乡医学院学报, 2023, 40(2): 181-186.
[26]	雷艳. 推拿治疗脾胃虚弱型小儿厌食的临床效果[J]. 中国医药导报, 2023, 20(27): 148-151.
[27]	唐其民, 涂一世. 杜克宽教授从五脏三层辨证法论治儿科疾病经验[J]. 中医儿科杂志, 2021, 17(1): 27-29.
[28]	陈丁丁,杨祥正. 杜克宽老中医“抑肝扶脾”思想初探[J]. 中医文献杂志,2009,27(4):35-36.
[29]	殷建群, 丁红梅, 任宗春, 等. 扶正健脾汤对脾胃虚弱型厌食症患儿免疫功能及微量元素的影响[J]. 海南医学, 2019, 30(23): 3037-3040.
[30]	杜晨光, 徐丁洁, 丁培杰, 等. 运脾消食颗粒对厌食症大鼠模型胃窦部胃泌素和血清八肽胆囊收缩素调节作用的研究[J]. 中华中医药学刊, 2016, 34(1): 160-162.

组别	n	显效	有效	无效	总有效
对照组	50	22（44.0）	20（40.0）	8（16.0）	42（84.0）
观察组	50	40（80.0）	9（18.0）	1（2.0）	49（98.0）^a

组别	n	尿D-木糖排泄率(%)		唾液淀粉酶活性比值
组别	n	治疗前	治疗后	治疗前		治疗后
对照组	50	15.88±2.98	22.45±3.73^a	0.93±0.04		1.02±0.13^a
观察组	50	15.83±2.99	28.72±5.15^a	0.92±0.03		1.29±0.22^a
t值		0.084	6.972	1.414		7.471
P值		0.933	0.000	0.161		0.000
组别	n	胃泌素（ng/L）		胃动素（ng/L）		神经肽Y（ng/L）
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	50	128.19±17.62	159.72±20.43^a	175.51±19.61	237.33±23.19^a	25.59±5.39	36.83±6.75^a
观察组	50	128.15±17.59	181.59±16.22^a	175.49±19.49	280.19±22.69^a	26.39±5.89	46.55±8.19^a
t值		0.011	5.928	0.005	9.341	0.709	6.476
P值		0.991	0.000	0.996	0.000	0.480	0.000

组别	n	进食量		食欲		进食时间
组别	n	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	50	5.11±0.29	1.82±0.25^a	5.15±0.23	1.62±0.42^a	5.08±0.23	1.42±0.14^a
观察组	50	5.09±0.25	0.49±0.13^a	5.13±0.22	0.53±0.15^a	5.07±0.22	0.62±0.13^a
t值		0.369	33.375	0.444	17.282	0.222	29.609
P值		0.713	0.000	0.658	0.000	0.825	0.000

组别	n	体质量（kg）		身高（m）
组别	n	治疗前	治疗后	治疗前	治疗后
对照组	50	19.54±5.13	19.69±5.22	1.09±0.15	1.12±0.19
观察组	50	19.53±5.15	19.76±5.42	1.09±0.11	1.13±0.15
t值		0.010	0.066	0.000	0.292
P值		0.992	0.948	1.000	0.771

Observation on the curative effect of Jianpi Yiqi ointment in treating anorexia(spleen and stomach qi-deficiency syndrome) in children

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