基于数据挖掘的王晓鸣教授治疗小儿积滞组方规律探索

doi:10.20274/j.cnki.issn.1674-3865.2025.06.002

Abstract

Abstract:

Objective To collate and analyze Professor Wang Xiaoming's traditional Chinese Medicine(TCM) prescriptions for pediatric food accumulation and stagnation, and summarize her clinical experience in medication for pediatric food accumulation and stagnation. Methods Prescription data from the outpatient department of Wang Xiaoming's Distinguished TCM Practitioner Studio in Zhejiang Province from January 1, 2019 to December 31, 2024 were collated and screened. Statistical software was employed to perform frequency analysis, analysis of medicinal properties (nature, flavor, channel tropism), analysis of medicinal efficacy, association rule analysis, and cluster analysis of the constituent herbs. Results A total of 382 prescriptions were screened out, identifying 19 high-frequency herbs. These herbs predominantly targeted the spleen, lung, stomach, and liver channels, with bitter, sweet, and pungent flavors being most common, and cold, warm, and neutral properties prevailing. The most frequently used herbs belonged to the categories of digestion-promoting, deficiency-tonifying and qi-regulating medicinals. The second-order association rule with the highest support was Fuling-Jineijin.The third-order association rule with the highest support was Baizhu-Fuling-Jineijin.Cluster analysis of high-frequency core herbs revealed two combinations. Conclusion Professor Wang's treatment for pediatric food accumulation and stagnation focuses on the core pathogenesis of "food accumulation leading to impaired spleen transportation, and qi stagnation, often accompanied by internal heat or liver qi stagnation." She establishes the core therapeutic principles of "promoting digestion and removing stagnation, strengthening the spleen and boosting qi, and regulating qi and harmonizing the middle Jiao." Innovatively, she emphasizes the simultaneous treatment of the liver and spleen and the clearance of stagnated heat.

Key words: Food accumulation and stagnation, WANG Xiaoming, Data mining, Prescription patterns, Child

CLC Number:

R725.7

Qing WANG, Yaqin CHEN, Danfei YIN, Suli WANG, Xiaoming WANG. Exploration of prescription patterns in Professor Wang Xiaoming's treatment for pediatric food accumulation and stagnation based on data mining[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2025, 17(6): 466-471.

Figures/Tables 9

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References 28

[1]	赵霞, 邱梦婷, 胡思源, 等. 儿童积滞中医诊疗指南[J]. 南京中医药大学学报, 2025, 41(4): 531-537.
[2]	吴捷, 王雪峰. 儿童功能性消化不良中西医结合诊治专家共识[J]. 中国实用儿科杂志, 2022, 37(1): 7-11.
[3]	赵霞, 李新民. 中医儿科学[M]. 5版. 北京: 中国中医药出版社, 2021: 150-154.
[4]	Oshima T. Functional dyspepsia: current understanding and future perspective[J]. Digestion, 2024, 105(1): 26-33.
[5]	Ford AC, Mahadeva S, Carbone MF, et al. Functional dyspepsia[J]. Lancet, 2020, 396(10263): 1689-1702.
[6]	Black CJ, Drossman DA, Talley NJ, et al. Functional gastrointestinal disorders: advances in understanding and management[J]. Lancet, 2020, 396(10263): 1664-1674.
[7]	Wauters L, Talley NJ, Walker MM, et al. Novel concepts in the pathophysiology and treatment of functional dyspepsia[J]. Gut, 2020, 69(3): 591-600.
[8]	Singh R, Zogg H, Ghoshal UC, et al. Current treatment options and therapeutic insights for gastrointestinal dysmotility and functional gastrointestinal disorders[J]. Front Pharmacol, 2022, 13: 808195.
[9]	Broeders BM, Carbone F, Balsiger LM, et al. Review article: functional dyspepsia-a gastric disorder, a duodenal disorder or a combination of both[J]? Aliment Pharmacol Ther, 2023, 57(8): 851-860.
[10]	Ford AC, Moayyedi P, Black CJ, et al. Systematic review and network meta-analysis: efficacy of drugs for functional dyspepsia[J]. Aliment Pharmacol Ther, 2021, 53(1): 8-21.
[11]	Sayuk GS, Prakash Gyawali C. Functional dyspepsia: diagnostic and therapeutic approaches[J]. Drugs, 2020, 80(13): 1319-1336.
[12]	Vandenberghe A, Schol J, Van den Houte K, et al. Current and emerging therapeutic options for the management of functional dyspepsia[J]. Expert Opin Pharmacother, 2020, 21(3): 365-376.
[13]	赵鲁卿, 时昭红, 张声生. 功能性消化不良中医诊疗专家共识意见(2023)[J]. 中华中医药杂志, 2024, 39(3): 1372-1378.
[14]	龚丽梅, 朱璐卡, 胡国华, 等. 柴胡疏肝散联合布拉氏酵母菌治疗小儿功能性消化不良的临床观察[J]. 中国实验方剂学杂志, 2020, 26(11): 136-141.
[15]	郑震云.王氏保赤丸治疗儿童功能性消化不良的疗效分析[J].当代医药论丛，2020,18(21):135-136.
[16]	袁海红, 翟纪功, 邢彦伟. 四君子汤加减联合小儿复方鸡内金咀嚼片治疗脾虚积滞型小儿厌食症的研究[J]. 中医研究, 2025, 38(2): 51-55.
[17]	易天霞, 宋程, 唐蔚, 等. 数据挖掘技术应用于名老中医经验传承的研究概况[J]. 湖南中医杂志, 2021, 37(8): 201-204.
[18]	李洪峥, 姜文睿, 赵鑫. 数据挖掘技术在中医名家学术经验传承中的应用[J]. 北京中医药, 2023, 42(2): 228-231.
[19]	谷晓红, 于河. 名老中医经验传承与创新的问题及策略[J]. 北京中医药大学学报, 2022, 45(9): 919-924.
[20]	中华中医药学会. 中医儿科常见病诊疗指南[M]. 北京: 中国中医药出版社, 2012: 22-23.
[21]	中华人民共和国药典委员会. 中华人民共和国药典（2020年版）[M]. 北京: 中国医药科学技术出版社, 2020.
[22]	Li YG, Wang XY, Chen HF, et al. Comparison of the chemical constituents of raw Fructus Aurantii and Fructus Aurantii stir-baked with bran, and the biological effects of auraptene[J]. J Ethnopharmacol, 2021, 269: 113721.
[23]	Zhu J, Tong H, Ye X, et al. The effects of low-dose and high-dose decoctions of fructus aurantii in a rat model of functional dyspepsia[J]. Med Sci Monit, 2020, 26: e919815.
[24]	Li HY, Lin GM, Fan JQ, et al. LC and molecular docking-based analysis of bitter compounds in Aurantii Fructus Immaturus and their bran-frying modulation on mitochondrial energy metabolism in STC rats[J]. J Ethnopharmacol, 2025, 355(Pt B): 120715.
[25]	钟民勇, 乔日发, 魏飞亭, 等. 枳壳、枳实胃肠动力作用及其机制的研究概况[J]. 江西中医药, 2021, 52(12): 68-71.
[26]	王晓鸣. 论《景岳全书》“和略” 与“和阵” 在儿科的应用[J]. 浙江中医杂志, 2018, 53(12): 905.
[27]	王晓鸣, 宋艳玲, 姚国芳. “和法” 论治儿科疾病体会[J]. 浙江中医杂志, 2022, 57(3): 195-196.
[28]	许佳烨, 程申, 杨育访, 等. 基于数据挖掘探讨王晓鸣教授诊治小儿再发性腹痛规律研究[J]. 中国中西医结合儿科学, 2024, 16(5): 449-454.

序号	中药	频次	频率(%)	序号	中药	频次	频率(%)
1	鸡内金	354	8.33	11	甘草	219	5.15
2	茯苓	347	8.16	12	薏苡仁	193	4.54
3	白术	330	7.76	13	连翘	191	4.49
4	枳壳	306	7.20	14	蝉蜕	125	2.94
5	白芍	303	7.13	15	莱菔子	76	1.79
6	柴胡	299	7.04	16	荷叶	67	1.58
7	山楂	286	6.73	17	石菖蒲	62	1.46
8	陈皮	275	6.47	18	当归	41	0.96
9	半夏	258	6.07	19	僵蚕	34	0.80
10	六神曲	233	5.48

后项	前项	支持度百分比	置信度百分比	实例	后项	前项	支持度百分比	置信度百分比	实例
茯苓	鸡内金	92.4	91.2	353	茯苓	柴胡	78.2	89.0	299
白术	鸡内金	92.4	86.1	353	白术	柴胡	78.2	85.2	299
鸡内金	茯苓	90.5	93.0	346	鸡内金	山楂	74.8	96.9	286
白术	茯苓	90.5	88.4	346	茯苓	山楂	74.8	89.5	286
茯苓	白术	86.3	92.7	330	白术	山楂	74.8	84.6	286
鸡内金	白术	86.3	92.1	330	茯苓	陈皮	72.0	92.7	275
白芍	白术	86.3	85.7	330	鸡内金	陈皮	72.0	90.2	275
鸡内金	枳壳	80.1	91.8	306	白术	陈皮	72.0	86.2	275
茯苓	枳壳	80.1	90.5	306	鸡内金	半夏	67.5	92.2	258
白术	枳壳	80.1	84.9	306	茯苓	半夏	67.5	90.3	258
白术	白芍	79.3	93.3	303	柴胡	半夏	67.5	89.1	258
茯苓	白芍	79.3	93.0	303	茯苓	六神曲	61.0	94.4	233
鸡内金	白芍	79.3	92.4	303	鸡内金	六神曲	61.0	94.4	233
鸡内金	柴胡	78.2	91.9	299	白术	六神曲	61.0	88.0	233

后项	前项	支持度（%）	置信度（%）	实例	后项	前项	支持度（%）	置信度（%）	实例
白术	茯苓+鸡内金	84.3	88.5	322	白术	山楂+鸡内金	72.5	84.5	277
鸡内金	白术+茯苓	80.1	93.1	306	茯苓	柴胡+鸡内金	72.0	89.5	275
白芍	白术+茯苓	80.1	86.6	306	白术	柴胡+鸡内金	72.0	85.0	275
茯苓	白术+鸡内金	79.6	93.8	304	鸡内金	柴胡+茯苓	69.6	92.5	266
白芍	白术+鸡内金	79.6	85.9	304	白术	柴胡+茯苓	69.6	88.0	266
茯苓	白芍+白术	74.1	93.6	283	茯苓	枳壳+白术	68.1	93.5	260
鸡内金	白芍+白术	74.1	92.2	283	鸡内金	枳壳+白术	68.1	91.5	260
白术	白芍+茯苓	73.8	94.1	282	白芍	枳壳+白术	68.1	85.8	260
鸡内金	白芍+茯苓	73.8	93.2	282	鸡内金	山楂+茯苓	67.0	98.0	256
茯苓	枳壳+鸡内金	73.6	91.1	281	白术	山楂+茯苓	67.0	87.1	256
白术	枳壳+鸡内金	73.6	84.7	281	白芍	山楂+茯苓	67.0	84.4	256
茯苓	白芍+鸡内金	73.3	93.9	280	茯苓	柴胡+白术	66.8	91.8	255
白术	白芍+鸡内金	73.3	93.2	280	鸡内金	柴胡+白术	66.8	91.8	255
鸡内金	枳壳+茯苓	72.5	92.4	277	鸡内金	陈皮+茯苓	66.8	91.0	255
茯苓	山楂+鸡内金	72.5	90.6	277	白芍	柴胡+白术	66.8	87.8	255
白术	枳壳+茯苓	72.5	87.7	277	白术	陈皮+茯苓	66.8	86.3	255

Exploration of prescription patterns in Professor Wang Xiaoming's treatment for pediatric food accumulation and stagnation based on data mining

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