Abstract: Objective
To study the effect of Anti-disease Sachet(a type of Zhuang medicine) on local immune function in Qi-deficiency mice, and to explore its mechanism in prevention and treatment of recurrent respiratory tract infection.
Methods
A total of 24 SPF mice of Kunming species were chosen(male and female), whose body mass was 18-22 g. They were randomly divided into four groups: blank group, model group, incense module group and sachet group, with 6 mice in each group. They were intervened by Anti-disease Sachet for 4 weeks, and at the fourth week, Qi-deficiency model was established; after that, ELISA was used to determine the concentration of sIgA and IgG in the alveolar lavage fluid.
Results
There was no statistical difference in sIgA in alveolar fluid between model group and sachet group(P>0.05). The sIgA in alveolar fluid of mice was significantly higher in sachet group than in blank group and model group, and there was statistical difference(P<0.05). There was no statistical difference in IgG in alveolar fluid of mice among the four groups(P>0.05).
Conclusion
Anti-disease Sachet(a type of Zhuang medicine) is effective in improving respiratory immune function, so it can be used to prevent recurrent respiratory tract infection in children.

Key words: Qi-deficiency, Anti-disease Sachet(a type of zhuang medicine), sIgA, IgG, Mice