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25 February 2011, Volume 3 Issue 1 Previous Issue    Next Issue

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Clinical randomized controlled study of 126 cases of acute nonbacterial infectious diarrhea  in children XU Hua,LIU Hua，ZENG Yongmei,et al 2011, 3 (1):  2-4.  doi: 10.3969/j.issn.1674-3865.2011.01.002 Abstract ( 311 )   PDF (344KB) ( 142 )   Save ObjectiveA randomized controlled clinical study of Chinese medicine in infantile diarrhea treatment was conducted to evaluate objectively and in a standard way the effect of main therapeutic method of Activating Spleen and Dissipating Dampness on infantile acute nonbacterial infectious diarrhea. MethodsThe clinical study was designed as a prospective, multicenter,randomized,control trial.Totally 126 infants with acute nonbacterial diarrhea were allocated into test group A,test group B and the control group in proportion of 1∶1∶1 with central randomization system.The treatment of Chinese herb,Chinese herb combined with massage and Montmorillonite powder was applied to the three groups respectively. ResultsSignificant effect rate in test group A,test group B and the control group was 51.16%，65.17%，34.15%，respectively,and there was a significant difference(P＜0.05) in the three groups.(2)On the second day of treatment,there was a significant difference on changing characters of stool in the three groups(P＜0.05).(3)The antidiarrheal time of test group A,test group B and the control group was （4.30±2.39）days，（4.31±2.79）days，（5.49±2.69）days，which showed no significant difference by statistical analysis(P＞0.05). ConclusionsChinese medicine group and Chinese herb combined with massage are superior to Montmorillonite powder on changing characters of stool. Related Articles | Metrics

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The effects of twostep sequential therapy on signal pathway of NFκB on airway inflammation in asthmatic mice YANG Zhaochuan,CHEN Lei,LIU Xiumei,et al 2011, 3 (1):  23-26.  doi: 10.3969/j.issn.1674-3865.2011.01.012 Abstract ( 454 )   PDF (413KB) ( 84 )   Save ObjectiveTo study the effects of twostep sequential therapy on signal pathway of NFκB of airway inflammation in asthmatic mice. MethodsForty healthy female Kunming mice were divided into four groups randomly(n=10,in each group):normal control group,asthma group,budesonide group and twostep sequential therapy group.The asthmatic models were established by ovalbumin,and budesonide and twostep sequential therapy were applied to them.Then the pathologic changes in airway tissues and bronchoalveolar lavage fluid(BALF) in cytology were observed.The level of nuclear factorκB(NFκB) and GATA3 in airway tissues was detected by immunohistochemical method.The level of interleukin4（IL4） in BALF was detected by enzymelinked immunosorbent assay(ELISA). ResultsThe treatment groups had less inflammatory cell infiltration than asthmatic group(P<0.01),and more than normal control group(P<0.01).There was no significant difference between the budesonide group and twostep sequential therapy group(P>0.05).The level of NFκB,GATA3 and IL4 decreased in the budesonide group and twostep sequential therapy group compared with the asthmatic group(P<0.01),but increased compared with the normal control group(P<0.01).There was no significant difference between budesonide group and twostep sequential therapy group(P>0.05). ConclusionsThe twostep sequential therapy may inhibit the activity of the signal transduction pathway of NFκB,which can reduce the expression of GATA3 and class cytokines of Th2,hence plays an important role in treating asthmatic mice． Related Articles | Metrics

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Clinical observation on combined treatment with sixingredient rehmannia pill for children with bronchial asthma LI Feng 2011, 3 (1):  26-28.  doi: 10.3969/j.issn.1674-3865.2011.01.013 Abstract ( 374 )   PDF (325KB) ( 111 )   Save ObjectiveObserve the safety and efficacy of combined treatment of sixingredient rehmannia pill for childhood bronchial asthma. MethodsA total of 50 children definitely diagnosed with asthma were randomly divided into two groups,25 in the combined group and 25 children in the control group.The combined group was treated with corticosteroids combined with sixingredient rehmannia pill.The control group was treated with corticosteroids alone.The safety and efficacy of the two groups were closely observed. ResultsAfter the treatment,the PEFR average point in the combined group was (200.33±28.11)L/s,which was higher than that in the control group (180.12±20.31)L/s,the difference having statistical significance.During the oneyear treatment,the average number of acute attack of asthma in the combined group and the control group was 0.69±0.62 and 1.34±0.42,respectively,which had statistical significance(P<0.05).As for the hospitalization of acute attack of asthma,the average number was 0.07±0.23 and 0.15±0.32,respectively,which had statistical significance(P<0.05).Respectively 25 children in the combined group and 19 children in the control group reached the normal expected PEFR number,which had statistical significance(P<0.05). ConclusionsThe curative effect of the combined application of sixingredient rehmannia pill for childhood bronchial asthma is significantly better than pure western medicine therapy. Related Articles | Metrics

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Research into the characteristic symptoms in TCM and the rule of evolvements of HFMD HU Yan，WANG Mengqing 2011, 3 (1):  29-32.  doi: 10.3969/j.issn.1674-3865.2011.01.014 Abstract ( 282 )   PDF (425KB) ( 192 )   Save ObjectiveTo analyze the symptomatic characteristics and evolution rule in terms of TCM in children with HFMD. MethodsInvestigate simultaneously at two clinical centers,collect TCM syndrome patterns of the HFMD and information of the four diagnostic methods and its relevant elements,fill in clinical observation forms,and build up database accordingly.The cases included in the database were classified according to the syndromes as:windheat invading lung,pathogenic dampness invading the lung and spleen,dampheat with exuberance of virulence,deficiency of qi and yin,toxicity invading heart and liver,water pathogen invading heart and liver,and deficiency of both yin and yang.Followup observation was made on children's clinical performance on the admission day(reference point),and also on the 3rd,5th and 7th day after medication treatments,so as to identify the TCM syndrome pattern.Apply the probabilistic method to children's HFMD,and systematically analyze the evolution rule of TCM syndrome of children's HFMD at different observation points. ResultsIt was found that children with HFMD mostly showed symptoms similar to herpes on hands and feet,and they were more likely to have mouth pain,fever and refuse to eat,and the difference had statistical significance(P<0.01）;windheat appeared more often than other symptoms,and the difference also had statistical significance（P＜0.05）.At an early stage,the main symptoms were mostly windheat invading lung,and pathogenic dampness invading the lung and spleen.The middle period was the vital stage when the excess type developed into deficiency.At the later stage although excess type was more likely to appear,the existing probabilities somewhat decreased,and the syndrome tended to transform into deficiency of qi and yin or normal state. ConclusionsThe child HFMD in most cases performs as windheat invading lung,and pathogenic dampness invading the lung and spleen ranks the second.Its TCM syndromes evolute as different patterns at different observation points. Related Articles | Metrics

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The research of effectiveness and mechanism of Danlong pantingarresting decoction in airway remodeling in asthmatic guinea pig MOU Deying，LIU Xiaofan 2011, 3 (1):  32-35.  doi: 10.3969/j.issn.1674-3865.2011.01.015 Abstract ( 237 )   PDF (486KB) ( 98 )   Save ObjectiveTo make a preliminary exploration of the effectiveness and mechanism of Danlong pantingarresting decoction in airway remodeling in asthmatic guinea pig. MethodsTwentyfour healthy female guinea pigs were divided into four groups randomly（n=6，in each group）：normal control group, model control group，dexamethasone group，and Danlong pantingarresting decoction group.The asthmatic guinea pig airway remodeling model was established by ovalbumin sensitized method,Danlong pantingarresting decoction was applied to intervene，and dexamethasone was used as control drug.After one month,detect the extent of airway remodeling and determine TGFβ1 level in guinea pig lung tissues. Results（1）Compared with normal group，WAt/Pi，WAm/Pi were significantly increased(P<0.05) in model group.Compared with model group，the airway wall thickness reduced in Danlong pantingarresting decoction group，there being a significant difference(P<0.05),but no significant difference compared with dexamethasone group(P>0.05).(2)Compared with normal group，the extent of lung tissue TGFβ1 was significantly increased in the model group(P<0.05).Compared with model group，the TGFβ1 content was decreased in Danlong pantingarresting decoction group，there being a significant difference(P<0.05),but no significant difference compared with the dexamethasone group(P>0.05). ConclusionsDanlong pantingarresting decoction plays an inhibitory role in airway remodeling of asthmatic guinea pigs.It may reduce the TGFβ1 level of lung tissues in asthmatic guinea pigs，thus inhibit airway proliferation of smooth muscle cells and extracellular matrix and block the airway remodeling process. Related Articles | Metrics