Abstract: ObjectiveTo make a preliminary exploration of the effectiveness and mechanism of Danlong pantingarresting decoction in airway remodeling in asthmatic guinea pig.
MethodsTwentyfour healthy female guinea pigs were divided into four groups randomly（n=6，in each group）：normal control group, model control group，dexamethasone group，and Danlong pantingarresting decoction group.The asthmatic guinea pig airway remodeling model was established by ovalbumin sensitized method,Danlong pantingarresting decoction was applied to intervene，and dexamethasone was used as control drug.After one month,detect the extent of airway remodeling and determine TGFβ1 level in guinea pig lung tissues.
Results（1）Compared with normal group，WAt/Pi，WAm/Pi were significantly increased(P<0.05) in model group.Compared with model group，the airway wall thickness reduced in Danlong pantingarresting decoction group，there being a significant difference(P<0.05),but no significant difference compared with dexamethasone group(P>0.05).(2)Compared with normal group，the extent of lung tissue TGFβ1 was significantly increased in the model group(P<0.05).Compared with model group，the TGFβ1 content was decreased in Danlong pantingarresting decoction group，there being a significant difference(P<0.05),but no significant difference compared with the dexamethasone group(P>0.05).
ConclusionsDanlong pantingarresting decoction plays an inhibitory role in airway remodeling of asthmatic guinea pigs.It may reduce the TGFβ1 level of lung tissues in asthmatic guinea pigs，thus inhibit airway proliferation of smooth muscle cells and extracellular matrix and block the airway remodeling process.

Key words: Asthma；Resolving phlegm/TCM therapy；Danlong pantingarresting decoction；Airway remodeling；Guinea pig；Animal, experiment